Chemical profile of the Anatolian Sideritis species with bioactivity studies

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Çarıkçı S.
Kılıç T.
Gören A. C.
Dirmenci T.

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Context: The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia. Objective: In this review article, Sideritis species growing in Turkey have been evaluated for phytochemical constituents and biological activities. Methods: The data for the isolates, components and extracts of the Anatolian Sideritis species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022. Results: In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish Sideritis species were reported. Anatolian Sideritis species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. Sideritis plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC–MS studies. Most of the diterpenoids of Turkish Sideritis species have ent-kaurene skeleton, among them linearol, siderol, 7-epicandicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. Their cytotoxic, enzyme inhibitory, antinociceptive and antistress activities were less frequently studied. Conclusions: Sideritis species should be considered promising therapeutic agents in the treatment of upper respiratory tract and ulcer/inflammatory diseases.



Tıp, Eczacılık, Temel Eczacılık Bilimleri, Yaşam Bilimleri, Biyoteknoloji, Moleküler Biyoloji ve Genetik, Sitogenetik, Sağlık Bilimleri, Temel Bilimler, Medicine, Pharmacology and Therapeutics, Basic Pharmaceutics Sciences, Life Sciences, Biotechnology, Molecular Biology and Genetics, Cytogenetic, Health Sciences, Natural Sciences, Klinik Tıp (MED), Yaşam Bilimleri (LIFE), Klinik Tıp, Farmakoloji ve Toksikoloji, Mikrobiyoloji, TROPİKAL TIP, ENTEGRE VE TAMAMLAYICI TIP, FARMAKOLOJİ VE ECZACILIK, BİYOKİMYA VE MOLEKÜLER BİYOLOJİ, BİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ, Clinical Medicine (MED), Life Sciences (LIFE), CLINICAL MEDICINE, PHARMACOLOGY & TOXICOLOGY, MOLECULAR BIOLOGY & GENETICS, MICROBIOLOGY, TROPICAL MEDICINE, INTEGRATIVE & COMPLEMENTARY MEDICINE, PHARMACOLOGY & PHARMACY, BIOCHEMISTRY & MOLECULAR BIOLOGY, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, Moleküler Tıp, Farmakoloji, Farmasötik bilim, İlaç Keşfi, Tamamlayıcı ve Alternatif Tıp, Molecular Medicine, Pharmacology, Pharmaceutical Science, Drug Discovery, Complementary and Alternative Medicine, diterpenoids, essential oils, flavonoids, glycosides, iridoids, phenolics, Secondary metabolites


Çarıkçı S., Kılıç T., Gören A. C., Dirmenci T., ALİM TORAMAN G. Ö., TOPÇU G., "Chemical profile of the Anatolian Sideritis species with bioactivity studies", Pharmaceutical Biology, cilt.61, sa.1, ss.1484-1511, 2023
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