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Chemical profile of the Anatolian Sideritis species with bioactivity studies

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dc.contributor.authorÇarıkçı S.
dc.contributor.authorKılıç T.
dc.contributor.authorGören A. C.
dc.contributor.authorDirmenci T.
dc.contributor.authorALİM TORAMAN G. Ö.
dc.contributor.authorTOPÇU G.
dc.contributor.institutionauthorALİM TORAMAN, GÜLBAHAR ÖZGE
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2023-12-20T21:50:42Z
dc.date.available2023-12-20T21:50:42Z
dc.date.issued2023-01-01
dc.description.abstractContext: The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia. Objective: In this review article, Sideritis species growing in Turkey have been evaluated for phytochemical constituents and biological activities. Methods: The data for the isolates, components and extracts of the Anatolian Sideritis species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022. Results: In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish Sideritis species were reported. Anatolian Sideritis species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. Sideritis plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC–MS studies. Most of the diterpenoids of Turkish Sideritis species have ent-kaurene skeleton, among them linearol, siderol, 7-epicandicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. Their cytotoxic, enzyme inhibitory, antinociceptive and antistress activities were less frequently studied. Conclusions: Sideritis species should be considered promising therapeutic agents in the treatment of upper respiratory tract and ulcer/inflammatory diseases.
dc.identifier.citationÇarıkçı S., Kılıç T., Gören A. C., Dirmenci T., ALİM TORAMAN G. Ö., TOPÇU G., "Chemical profile of the Anatolian Sideritis species with bioactivity studies", Pharmaceutical Biology, cilt.61, sa.1, ss.1484-1511, 2023
dc.identifier.doi10.1080/13880209.2023.2280253
dc.identifier.endpage1511
dc.identifier.issn1388-0209
dc.identifier.issue1
dc.identifier.pubmed37990887
dc.identifier.scopus85177695997
dc.identifier.startpage1484
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85177695997&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38850
dc.identifier.volume61
dc.relation.ispartofPharmaceutical Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectPharmacology and Therapeutics
dc.subjectBasic Pharmaceutics Sciences
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectMikrobiyoloji
dc.subjectTROPİKAL TIP
dc.subjectENTEGRE VE TAMAMLAYICI TIP
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMICROBIOLOGY
dc.subjectTROPICAL MEDICINE
dc.subjectINTEGRATIVE & COMPLEMENTARY MEDICINE
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectMoleküler Tıp
dc.subjectFarmakoloji
dc.subjectFarmasötik bilim
dc.subjectİlaç Keşfi
dc.subjectTamamlayıcı ve Alternatif Tıp
dc.subjectMolecular Medicine
dc.subjectPharmacology
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectComplementary and Alternative Medicine
dc.subjectditerpenoids
dc.subjectessential oils
dc.subjectflavonoids
dc.subjectglycosides
dc.subjectiridoids
dc.subjectphenolics
dc.subjectSecondary metabolites
dc.titleChemical profile of the Anatolian Sideritis species with bioactivity studies
dc.typearticle
dspace.entity.typePublication
local.avesis.ide79eb472-dc27-4400-bcb1-faeeb6f8608a
relation.isAuthorOfPublication210aea46-dd30-4501-bf3e-ada7c113bb01
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication.latestForDiscovery210aea46-dd30-4501-bf3e-ada7c113bb01
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