Publication: Does hormonal control obviate positive airway pressure therapy in acromegaly with sleep-disordered breathing?
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Akkoyunlu, MUHAMMED EMİN
Ilhan, MAHMUT MUZAFFER
Bayram, MEHMET
Tasan, ERTUĞRUL
YAKAR, Fatih
OZCELIK, Hatice Kutbay
KARAKOSE, Fatmanur
Kart, Levent
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Abstract
Acromegaly is a disease in which uncontrolled release of growth hormone occurs
after closure of epiphyseal plates, causing changes in the body that can lead to sleep disordered breathing (SDB). No definite guidelines regarding the treatment of SDB in acromegaly
are available. In this study, we aimed to investigate the prevalence of SDB in acromegaly
and whether hormonal control alters the necessity of positive airway pressure (PAP) therapy
in acromegaly patients with SDB.
Methods: Forty-two acromegaly patients were included in the study and divided into two
groups according to disease status, i.e., active or well controlled. All patients underwent polysomnography. Fourteen patients with active acromegaly were diagnosed with SDB and were
evaluated for PAP therapy with polysomnography both before and 6 months after disease control was achieved.
Results: Sleep-disorder breathing was diagnosed in 22 of 42 patients, 7 of 20 patients with
controlled-disease and 15 of 20 patients with active diseases. There were significant reductions in respiratory disturbance index (RDI), apnea index, desaturation index, central apnea
number, and rapid eye movement-phase RDI at the control polysomnography. Initially, PAP
therapy was indicated in 12 of 14 patients and PAP therapy indication held in 11 patients after
acromegaly control was achieved.
Conclusion: Our study revealed that over half of patients with acromegaly had SDB. Furthermore, SDB severity decreases with acromegaly treatment; however, this decrease does not
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Akkoyunlu M. E. , Ilhan M. M. , Bayram M., Tasan E., YAKAR F., OZCELIK H. K. , KARAKOSE F., Kart L., -Does hormonal control obviate positive airway pressure therapy in acromegaly with sleep-disordered breathing?-, RESPIRATORY MEDICINE, cilt.107, ss.1803-1809, 2013