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Does hormonal control obviate positive airway pressure therapy in acromegaly with sleep-disordered breathing?

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dc.contributor.authorAkkoyunlu, MUHAMMED EMİN
dc.contributor.authorIlhan, MAHMUT MUZAFFER
dc.contributor.authorBayram, MEHMET
dc.contributor.authorTasan, ERTUĞRUL
dc.contributor.authorYAKAR, Fatih
dc.contributor.authorOZCELIK, Hatice Kutbay
dc.contributor.authorKARAKOSE, Fatmanur
dc.contributor.authorKart, Levent
dc.contributor.institutionauthorAKKOYUNLU, MUHAMMED EMİN
dc.contributor.institutionauthorİLHAN, MAHMUT MUZAFFER
dc.contributor.institutionauthorBAYRAM, MEHMET
dc.contributor.institutionauthorTAŞAN, ERTUĞRUL
dc.contributor.institutionauthorOKYALTIRIK, FATMANUR
dc.date.accessioned2019-10-05T15:01:23Z
dc.date.available2019-10-05T15:01:23Z
dc.date.issued2013-11-01
dc.description.abstractAcromegaly is a disease in which uncontrolled release of growth hormone occurs after closure of epiphyseal plates, causing changes in the body that can lead to sleep disordered breathing (SDB). No definite guidelines regarding the treatment of SDB in acromegaly are available. In this study, we aimed to investigate the prevalence of SDB in acromegaly and whether hormonal control alters the necessity of positive airway pressure (PAP) therapy in acromegaly patients with SDB. Methods: Forty-two acromegaly patients were included in the study and divided into two groups according to disease status, i.e., active or well controlled. All patients underwent polysomnography. Fourteen patients with active acromegaly were diagnosed with SDB and were evaluated for PAP therapy with polysomnography both before and 6 months after disease control was achieved. Results: Sleep-disorder breathing was diagnosed in 22 of 42 patients, 7 of 20 patients with controlled-disease and 15 of 20 patients with active diseases. There were significant reductions in respiratory disturbance index (RDI), apnea index, desaturation index, central apnea number, and rapid eye movement-phase RDI at the control polysomnography. Initially, PAP therapy was indicated in 12 of 14 patients and PAP therapy indication held in 11 patients after acromegaly control was achieved. Conclusion: Our study revealed that over half of patients with acromegaly had SDB. Furthermore, SDB severity decreases with acromegaly treatment; however, this decrease does noten
dc.identifier
dc.identifier.citationAkkoyunlu M. E. , Ilhan M. M. , Bayram M., Tasan E., YAKAR F., OZCELIK H. K. , KARAKOSE F., Kart L., -Does hormonal control obviate positive airway pressure therapy in acromegaly with sleep-disordered breathing?-, RESPIRATORY MEDICINE, cilt.107, ss.1803-1809, 2013
dc.identifier.doi10.1016/j.rmed.2013.08.043
dc.identifier.pubmed24074722
dc.identifier.scopus84887059057
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5247
dc.identifier.wosWOS:000327230800020
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleDoes hormonal control obviate positive airway pressure therapy in acromegaly with sleep-disordered breathing?
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of vector borne diseases
local.avesis.id80e88204-fad5-4f58-b57c-284cb769e1ba
local.avesis.response5117
local.publication.isinternational1
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relation.isAuthorOfPublication03a7dcd2-c33d-41cc-96f8-cb42f0b95200
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relation.isAuthorOfPublication6356cfb4-7ab2-4a3d-b37d-263c86174772
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relation.isAuthorOfPublication.latestForDiscovery6df71d2f-97bd-4028-88d7-8384cb4bf22f
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