Publication: Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases
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Date
2017-08-01
Authors
Dinc, Harika Oyku
SOHRABİ, Pari
Habip, Zafer
Saribas, Suat
Vatan, Asli
Altun, Yagiz M.
ZİVER, Tevhide
Caliskan, Reyhan
Demirci, Mehmet
Uysal, Omer
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Abstract
Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.
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SOHRABİ P., Habip Z., Saribas S., Vatan A., Dinc H. O. , Altun Y. M. , ZİVER T., Caliskan R., Demirci M., Uysal O., et al., -Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases-, FUTURE VIROLOGY, cilt.12, ss.409-419, 2017