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YÜKSEL MAYDA, PELİN

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PELİN

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YÜKSEL MAYDA

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    Publication
    The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia--the risk factor or an indication of a contact with cat?
    (2010-06-01T00:00:00Z) Yuksel, PELİN; ALPAY, N; BABUR, C; BAYAR, R; SARIBAS, S; KARAKOSE, AR; AKSOY, C; ASLAN, M; MEHMETALI, S; KILIC, S; BALCIOGLU, I; HAMANCA, O; DIRICAN, A; KUCUKBASMACI, O; ONER, A; TORUN, MM; KOCAZEYBEK, B; YÜKSEL MAYDA, PELİN
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    Can the nucleic acid amplification test (NAT) be an alternative to the serologic tests? A prospective study, the results of 18,200 blood donors from the Turkish Red Crescent
    (2010-12-01T00:00:00Z) Kosan, Erdogan; Kocazeybek, Bekir; Altunay, Husnu; Aymelek, Meryem; Alan, Esra; Saribas, Suat; Aslan, Mustafa; Yenen, Osman Sadi; Yuksel, PELİN; Birinci, Ilhan; Kirali, Kaan; Aksoy, Armagan; YÜKSEL MAYDA, PELİN
    Aim: Serologic tests having high sensitivity and specificity are used in order to prevent contamination with infectious agents from blood and blood products for transfusion safety. The present serologic tests have problems such as low sensitivity and weak detection capacity of infectious agents in the -window period-. We aimed to test the use of NAT (Nucleic Acid Amplification Test) in routine blood screening in the Blood Bank.
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    Does borna disease virus (BDV) have a role in the etiopathogenesis of schizophrenia?
    (2011-05-04T00:00:00Z) Karakose, A. R.; Yuksel, P.; Turan, N.; Ziver, T.; Saribas, S.; Alpay, Nihat; Balcioglu, I; Aslan, M.; Helps, C. R.; Yilmaz, H.; Kocazeybek, B.; YÜKSEL MAYDA, PELİN
    In human, certain serological and molecular trials estimated an association between psychiatric diseases, particularly schizophrenia, mood disorders and borna disease virus (BDV). The purpose of this study was to investigate whether BDV has association with etiopathogenesis of schizophrenia. A total of 207 patients who were diagnosed with residual schizophrenia and 51 patient control grop with 134 healthy control group were included in the study. RNA of borna disease virus (BDV p24 and p40) in the peripheral blood was investigated by using real-time RT-PCR. A highly significant difference was detected between patient and healthy control group cases in terms of BDV IgG seropositivity (p<0.001). The OD value of IgG positivity was established as significantly high in the patient group compared to patient control group in the age groups of 35-50 and 51-65 (p<0.001). No significant differences were detected in other groups. The OD value of IgG positivity was established as significantly high in the patient group compared to healthy control group in the age groups of 35-50 and 51-65 (p<0.001). BDV-RNA (p24 and p40) was not detected in those 102 cases having BDV-IgG seropositivity.
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    İ.Ü. Cerrahpaşa Tıp Fakültesi Tıbbi Mikrobiyoloji Seroloji/Elısa Ünitesine Gelen Serumlarda EBV Seropozitifliğinin Retrospektif Olarak 1,5 Yıllık Seroepidemiyolojik Değerlendirilmesi
    (2016-02-25T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; bakır, esra; YÜKSEL MAYDA, PELİN; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
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    Can cystic Echinococcosis trigger autoimmunity?
    (2010-03-01T00:00:00Z) Aslan, M.; Oner, Y. A.; Saribas, S.; Polat, E.; CAKAN, H.; Yuksel, PELİN; Zengin, K.; ARIKAN, S.; Torun, M. M.; Kocazeybek, B.; YÜKSEL MAYDA, PELİN
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    The role of Chlamydophila pneumoniae in the etiopathogenesis of schizophrenia and brain-derived neurotrophic factor (BDNF), neurotrophins like neurotrophin 3 (NT3) levels: A worldwide retrospective study
    (2014-04-01T00:00:00Z) Kalayci, F.; Balcioglu, I.; Özdemir, Aydoğan; Yuksel, PELİN; ALPAY, N.; Ergin, Selma; Kuskucu, M.; Kurt, A.; Poyraz, C. Aksoy; Tokman, H. Bahar; Kocazeybek, B.; YÜKSEL MAYDA, PELİN
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    Publication
    Point Mutations at gyrA and gyrB Genes of Levofloxacin Resistant Helicobacter pylori Strains and Dual Resistance with Clarithromycin
    (2021-01-01T00:00:00Z) Ziver-Sarp, Tevhide; YÜKSEL MAYDA, PELİN; Saribas, Suat; DEMİRYAS, Süleyman; Gareayaghi, Nesrin; ERGİN, Sevgi; TAŞÇI, İhsan; Ozbey, Dogukan; BAL, Kadir; Erzin, Yusuf; AKKUŞ, Seher; BAHAR TOKMAN, Hrisi; Demirci, Mehmet; Tufan-Kocak, Banu; KOCAZEYBEK, Bekir Sami; YÜKSEL MAYDA, PELİN
    Background: Spontaneous point mutations in genes encoding gyrA/B subunits of DNA gyrase are responsible for fluoroquinolone resistance. We aimed to determine the clarithromycin and levofloxacin resistance phenotypically in H. pylori strains and to investigate the mutations responsible for levofloxacin resistance and the effects of these mutations on dual antibiotic resistance. Methods: A total of 65 H. pylori isolates were included. The E-test method was used for the clarithromycin and le-vofloxacin antimicrobial susceptibility test. Real-time PCR was used to detect the point mutations. Results: Twenty-four (36.9%) of 65 H. pylori strains were phenotypically resistant to clarithromycin and 14 (21.5%) to levofloxacin. The phenotypic levofloxacin resistance rate of strains with Asn87Lys and Asp91Asn mu-tations were significantly higher (gyrA gene) (p < 0.05). The phenotypic levofloxacin resistance rate of strains with Arg484Lys and Asp481Glu mutations were significantly higher (gyrB gene) (p < 0.05). The Asn87Lys mutation in-creased the risk of phenotypes being resistant to levofloxacin 70.156 times and Asp91Asn mutation increased 125,427 times higher. Seven (10.8%) of 65 H. pylori strains showed dual resistance to both levofloxacin and cla-rithromycin. The rate of being dual resistant with A2143G mutation (clarithromycin resistance) was found to be significantly higher (p < 0.05). Conclusions: The Asn87Lys and Asp91Asn mutations in the gyrA gene had a phenotypically enhancing effect on levofloxacin resistance, while the presence of Asp481Glu and Arg484Lys mutations in the gyrB gene did not. The existence of dual resistance was developed with the increase in clarithromycin and levofloxacin resistance rates. (Clin. Lab. 2021;67:2369-2377. DOI: 10.7754/Clin.Lab.2021.210843)
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    Relationship between fecal calprotectin level and disease activity in patients with hidradenitis suppurativa
    (2020-03-01T00:00:00Z) Eser, Emel; Engin, Burhan; Yuksel, PELİN; Kocazeybek, Bekir Sami; Kutlubay, Zekayi; Serdaroglu, Server; Askin, Ozge; YÜKSEL MAYDA, PELİN
    Background Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with recurrent abscesses, and sinus tract formation leading to scarring. Calprotectin has immunomodulatory, antimicrobial, and antiproliferative properties and is a calcium-binding protein primarily found in the neutrophil cytoplasm. In recent years, a significant relationship between the activity of various diseases and the level of calprotectin has led to the conclusion that there may be a similar relationship in hidradenitis suppurativa.
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    Are isolated anti-HBc blood donors in high risk group? The detection of HBV DNA in isolated anti-HBc cases with nucleic acid amplification test (NAT) based on transcription-mediated amplification (TMA) and HBV discrimination.
    (2010-12-01T00:00:00Z) ALTUNAY, H; KOSAN, E; BIRINCI, I; AKSOY, A; KIRALI, K; SARIBAS, S; ASLAN, M; Yuksel, PELİN; ALAN, E; YENEN, OS; KOCAZEYBEK, B; YÜKSEL MAYDA, PELİN
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    Publication
    History of Epidemics and COVID-19
    (2020-12-01T00:00:00Z) YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    In archaeological excavations, it has been reported that formations resembling bacterial fossils are found among the rock layers and they belong to millions of years ago. There are those who have created the flora and preserved us by creating our flora, and those that have brought us to the end, as well as those that help us to form the microorganisms that we share with the same planet, whose existence dates back to ancient times. Although our immune system and medical facilities are trump cards against microorganisms living in the world for much longer than human beings, these are not always enough to protect us, and microorganisms are causing outbreaks that will make history. In this review, we aimed to examine the epidemic diseases experienced by human beings from past to present and their effects.