Publication: An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge
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Date
2022-02-01T00:00:00Z
Authors
Rider, Paul J. F.
KAMIL, MOHD
Yilmaz, Ilknur
Atmaca, Habibe N.
Kalkan-Yazici, Merve
Ziya Doymaz, Mehmet
Kousoulas, Konstantin G.
ALY, Ahmed Sayed Ibrahım
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Abstract
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.
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Keywords
EXP1, HSV-1, TMP21, UIS3, VC2, intramuscular, liver stage, malaria vaccine, subcutaneous, viral vector