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An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge

dc.contributor.authorRider, Paul J. F.
dc.contributor.authorKAMIL, MOHD
dc.contributor.authorYilmaz, Ilknur
dc.contributor.authorAtmaca, Habibe N.
dc.contributor.authorKalkan-Yazici, Merve
dc.contributor.authorZiya Doymaz, Mehmet
dc.contributor.authorKousoulas, Konstantin G.
dc.contributor.authorALY, Ahmed Sayed Ibrahım
dc.contributor.institutionauthorKAMIL, MOHD
dc.contributor.institutionauthorYAZICI, MERVE
dc.contributor.institutionauthorALY, AHMED SAYED IBRAHıM
dc.date.accessioned2022-03-15T20:59:40Z
dc.date.available2022-03-15T20:59:40Z
dc.date.issued2022-02-01T00:00:00Z
dc.description.abstractHere, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.
dc.identifier.doi10.3390/vaccines10020300
dc.identifier.pubmed35214758
dc.identifier.scopus85124832549
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30452
dc.identifier.wosWOS:000762309700001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEXP1
dc.subjectHSV-1
dc.subjectTMP21
dc.subjectUIS3
dc.subjectVC2
dc.subjectintramuscular
dc.subjectliver stage
dc.subjectmalaria vaccine
dc.subjectsubcutaneous
dc.subjectviral vector
dc.titleAn Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaa1665e3-d973-43ba-b079-5e56c94f466c
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication47a38002-6a0b-4c36-b83d-773a943d999d
relation.isAuthorOfPublication.latestForDiscovery90dbf8d7-063b-4fdc-9373-f3678809a1ea
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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