Publication: DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS
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Date
2024-01-01
Authors
Authors
Esentürk-Güzel I.
ALĞIN YAPAR E.
Cavalu S.
ŞEKER İ. T.
İNAL E.
KARTAL M.
Koç R. Ç.
Öztürk R. Y.
Göksu F.
Bölek S.
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Abstract
The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2-268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.
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Keywords
Eczacılık, Temel Eczacılık Bilimleri, Yaşam Bilimleri, Sağlık Bilimleri, Temel Bilimler, Pharmacology and Therapeutics, Basic Pharmaceutics Sciences, Life Sciences, Health Sciences, Natural Sciences, Yaşam Bilimleri (LIFE), Farmakoloji ve Toksikoloji, FARMAKOLOJİ VE ECZACILIK, Life Sciences (LIFE), PHARMACOLOGY & TOXICOLOGY, PHARMACOLOGY & PHARMACY, Genel Farmakoloji, Toksikoloji ve Eczacılık, General Pharmacology, Toxicology and Pharmaceutics, biocompatibility, electrospinning, hdroxypropylcellulose, nanofibers, polyvinyl pyrollidone, propolis
Citation
Esentürk-Güzel I., ALĞIN YAPAR E., Cavalu S., ŞEKER İ. T., İNAL E., KARTAL M., Koç R. Ç., Öztürk R. Y., Göksu F., Bölek S., et al., "DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS", Farmacia, cilt.72, sa.1, ss.200-213, 2024