Person: KARTAL, MURAT
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Publication DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS(2024-01-01) Esentürk-Güzel I.; ALĞIN YAPAR E.; Cavalu S.; ŞEKER İ. T.; İNAL E.; KARTAL M.; Koç R. Ç.; Öztürk R. Y.; Göksu F.; Bölek S.; et al.; İNAL, EBRAR; KARTAL, MURATThe aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2-268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.Publication Effects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.(2019-11-10T00:00:00Z) Demirbolat, İ; Ekinci, C; Nuhoğlu, F; Yıldız, PELİN; Geçer, MÖ; KARTAL, MURAT; YILDIZ, PELİNDiabetes mellitus is a multisystemic metabolic disorder that may affect the eyes, kidneys, vessels, and heart. Chronic hyperglycemia causes non-enzymatic glycation of proteins and elevation of the polyol pathway resulting in oxidative stress that damages organs. The current study aimed to investigate the dose-dependent effects of orally consumed Rosa damascena Mill. hydrosol on hematology, clinical biochemistry, lens enzymatic activity, and lens pathology in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male Sprague-Dawley rats by intraperitoneal administration of STZ (40 mg/kg body weight). Rose hydrosols containing 1515 mg/L and 500 mg/L total volatiles (expressed as citronellol) were introduced to rats orally for 45 days. Consumption of 1515 mg/L volatile containing rose hydrosol successfully ameliorated hematologic, hepatic, and renal functions. Hydrosols also attenuated hyperglycemia and decreased the advanced glycation end-product formation in a dose-dependent manner. Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Histopathological examinations of rat lenses also indicated that increasing the dose of rose hydrosol had a protective effect on lenses in diabetic conditions. Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. The present results suggest that rose hydrosol exerts significant protective properties in diabetes mellitus and has no toxic effect on all studied systems in healthy test groups.Publication Cytotoxic Activities of Several Geranyl-Substituted Flavanones(2010-04-01T00:00:00Z) SMEJKAL, Karel; SVACINOVA, Jana; SLAPETOVA, Tereza; SCHNEIDEROVA, Kristyna; DALL'ACQUA, Stefano; INNOCENTI, Gabbriella; ZAVALOVA, Veronika; KOLLAR, Peter; CHUDIK, Stanislav; MAREK, Radek; JULINEK, Ondrej; URBANOVA, Marie; Kartal, MURAT; CSOELLEI, Marek; DOLEZAL, Karel; KARTAL, MURATNine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Moms alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the TIP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3) and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including gentnyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.Publication SPORCULARDA FİZİKSEL VE MENTAL PERFORMANSIN ARTIRILMASINDA GİNSENG KULLANIMI(2020-02-01T00:00:00Z) Kartal, Murat; KARTAL, MURATSporcuların performansını etkileyen temel faktörlerin başında genetik yapı, uygun antrenman ve beslenme gelmektedir. Yüksek sportif performansın oluşumunda, kişiye ait fizyolojik ve psikolojik faktörler, antrenman durumu, beslenme durumu, sağlık, çevresel faktörler, spora özgü özellikler rol oynamakla birlikte hangi faktörün maksimum performansta daha etkili olduğunu söylemek güçtür (Yarar ve ark., 2011).Publication Bitkisel Metabolitler ile probiyotiklerin sinerjik antagonistik etkileşimleri(2020-10-01T00:00:00Z) Kartal, Murat; KARTAL, MURATPublication Selective Cholinesterase Inhibitors from Buxus sempervirens L. and their Molecular Docking Studies(2011-12-01T00:00:00Z) Orhan, Ilkay E.; KHAN, Mahmud T. H.; Erdem, Sinem A.; Kartal, MURAT; Sener, Bilge; KARTAL, MURATIn this work, two alkaloids namely (+)-buxabenzamidienine (1) and (+)-buxamidine (2) were isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation method. Their acetyl-(AChE) and butyrylcholinesterase (BChE) inhibitory activities were studied and the compounds were found to be quite selective inhibitors of AChE. IC50 values of compound 1 for electric eel AChE and horse BChE were 0.787 and 7.68 mM, respectively; while the corresponding IC50 of compound 2 were 1.70 and 549.98 mM, respectively. Theoretical (quantum mechanical, homology modelling and docking) calculations were performed in order to explain their interactions with different AChE (electric eel and human) and BChE (horse and human). The x-ray crystal structures of electric eel AChE, human AChE, human BChE and a model of horse BChE constructed by homology with human BChE were used for docking of compounds 1 and 2. Density functional theory (DFT) calculations of the compounds were performed at the B3LYP/6-31G** level using the program Spartan (TM), and their HOMO and LUMO energy levels were calculated. Docking studies exhibited that compound 1 interacts with the acyl-binding pocket of the active site gorge of huAChE, and including several other hydrophobic interactions.Publication Mersin Yaprağı Uçucu Yağı(2019-01-01T00:00:00Z) Kartal, Murat; KARTAL, MURATPublication Analysis of pomegranate juice components in rat corpora cavernosal relaxation(2014-03-01T00:00:00Z) OZTEKIN, C. V.; Gur, S.; Abdulkadir, N. A.; Kartal, MURAT; KARABAKAN, M.; AKDEMIR, A. O.; GOKKAYA, C. S.; CETINKAYA, MURAT; KARTAL, MURAT; ÇETİNKAYA, MURATThis study evaluated the action of pomegranate juice (PJ) and its five principal phenolic constituents on rat corpus cavernosum smooth muscle (CCSM). Isometric tension studies were performed after precontraction with phenylephrine in CCSM from rats. Relaxant responses to PJ and its constituents ellagic acid (EA), chlorogenic acid, caffeic acid, cumaric acid and rutin were investigated. PJ and EA caused CCSM relaxations (94.1 +/- 3.7 and 51.3 +/- 9.9%), while others induced limited relaxant responses. EA response was not inhibited by L-N(G)-nitroarginine methyl ester (100 mu M) and 1H-[1,2,4]-oxadiazolo[4,3-a] quinoxalin-1-one (1 mu M). Tetraethylammonium (100 mu M) and apamin (10 mu M) and nifedipine (10 mu M) inhibited EA-induced relaxations at 10(-3) M by 84%, 82% and 78%, respectively. Glibenclamide (10 mu M) inhibited EA response (97%, 100 mu M). PJ-induced relaxation was not altered by several inhibitors. EA was estimated to be responsible for 13.3% of relaxation caused by PJ. Our study demonstrated that PJ and EA-induced marked relaxations in CCSM. The opening of Ca(2 + )-activated K + channels and the inhibition of Ca(2 + )-channels regulate the relaxation by EA, but not PJ. EA has a minor contribution to the marked relaxation obtained by PJ, suggesting the presence of other PJ constituents, which induce nitric oxide-independent corporal relaxation. Further studies are needed to examine the potential of PJ in combination with a PDE5 inhibitor in ED.Publication Development of phytoactive essential oils-composed organogels against oral pathogens(2024-08-01) ALĞIN YAPAR E.; Gökçe E. H.; Şahiner A.; İNAL E.; ULUSOY Ş.; Souto E. B.; Akanoğlu B.; KARTAL M.; İNAL, EBRAR; ULUSOY, ŞEYMA; KARTAL, MURATGingivitis, one of the most common periodontal diseases, is the inflammation of the gingival tissues that causes swelling, tenderness, redness and bleeding. The treatment should contain anti-inflammatory, antibacterial, and antioxidant agents to decrease the risk of dental plaque formation and periodontal tissue damage in the inflammatory process. In line with the antibacterial, antifungal, and antioxidant effects of the geranium (Pelargonium graveolens L\"Hér.) herb, common sage (Salvia officinalis L.) herb, and mastic tree (Pistacia lentiscus L.) leaf, in this work we propose their use as active pharmaceutical ingredients of periodontal gels. The organogel formulations were produced either by microwave-assisted irradiation method or by the conventional approach (microwave-free), and further characterized for their physicochemical properties, antimicrobial efficacy and cell viability. Among them, the gel formulation containing 4 % geranium essential oil obtained by the conventional method was identified as the best candidate to be developed as an effective and safe alternative suitable for oromucosal applications.Publication Development and validation of a GC-FID method to quantify thymoquinone in black cumin seed oils(2019-01-01T00:00:00Z) Demirbolat, Ilker; KARTAL, MURAT; Karik, Unal; KARTAL, MURATBlack cumin (Nigella sativa L.) is a very popular medicinal plant around the world. Pharmacological effects have been widely studied over the years. It has an economic importance and being cultivated in many parts of Turkey and neighbour countries. Thymoquinone (TQ) is a volatile compound found in black cumin seeds and a major compound of its essential and fixed oils which has been reported as anticancer, antidiabetic, spasmolytic, immunomodulator, bronchodilator, antimicrobial, analgesic, anti-inflammatory, antioxidant etc. The quality of black cumin seed oil depends on extraction technics (expression, super critic CO2 extraction etc.), quality of seeds, storage time and thymoquinone content. In this study we developed and validated a rapid quantification GC-FID method to determine the thymoquinone levels in seed oils which uses diethyl phthalate (DEP) as an internal standard.