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Now showing 1 - 6 of 6
  • PublicationMetadata only
    Alzheimer Hastalığı ve Doğal Kaynaklı Bileşikler
    (2021-12-01T00:00:00Z) Ulusoy, Şeyma; Kartal, Murat; İnal, Ebrar; ULUSOY, ŞEYMA; KARTAL, MURAT; İNAL, EBRAR
  • PublicationOpen Access
    Variations in Chemical Compositions and Biological Activities of Artemisia vulgaris L. (Common Mugwort) Essential Oils at Different Growth Stages
    (2022-06-01T00:00:00Z) Demirbolat, İlker; İnal, Ebrar; Ulusoy, Şeyma; Kartal, Murat; İNAL, EBRAR; ULUSOY, ŞEYMA; KARTAL, MURAT
  • PublicationMetadata only
    Pektinin Kimyasal Yapısı, Özellikleri ve Ekonomik Önemi: Eczacılık ve Kozmetikte Kullanımı
    (2021-12-01T00:00:00Z) İnal, Ebrar; Kartal, Murat; Ulusoy, Şeyma; İNAL, EBRAR; KARTAL, MURAT; ULUSOY, ŞEYMA
  • PublicationMetadata only
    Bitkisel Droglarda Kalite Kontrol
    (İksad Yayınevi, 2022-10-01) Kartal M.; Ulusoy Ş.; İnal E.; KARTAL, MURAT; ULUSOY, ŞEYMA; İNAL, EBRAR
  • PublicationMetadata only
    Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities
    (2023-12-01) İnal E.; Nath E. Ö.; Abudayyak M.; Ulusoy Ş.; İnan H. A.; Cicek M.; Kartal M.; İNAL, EBRAR; ULUSOY, ŞEYMA; KARTAL, MURAT
    The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plantVitex agnus-castusL. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of theV. agnus-castusEO’sin-vitrocytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits ofV. agnus-castuswere analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of theV. agnus-castus. EOs extracted from Balıkesir region were defined as the \"α-pinene-1,8-cineole\" chemotype, while EOs extracted from İstanbul region were defined as the \"sabinene-1,8-cineole\" chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze thein-vitrocytotoxic effects of flowers. This study is also the first to show thein-vitrocytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC50 is about 4.68 µg/mL on the MCF7 cell line- than İstanbul regions, which might be attributed to the higher amount ofα-pinene, caryophyllene, and limonene content. Our results indicated that theV. agnus-castusEOs, which containα-pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.
  • PublicationMetadata only
    (2024-01-01) Esentürk-Güzel I.; ALĞIN YAPAR E.; Cavalu S.; ŞEKER İ. T.; İNAL E.; KARTAL M.; Koç R. Ç.; Öztürk R. Y.; Göksu F.; Bölek S.; et al.; İNAL, EBRAR; KARTAL, MURAT
    The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2-268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.