Publication: The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.
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MALYA, FATMA ÜMİT
KADIOGLU, HÜSEYİN
BEKTASOGLU, HÜSEYİN KAZIM
Gucin, ZÜHAL
YILDIZ, S
GUZEL, MEHMET
ERDOGAN, EZGİ BAŞAK
YUCEL, S
ERSOY, YELİZ EMİNE
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Abstract
Abstract
Objective: To investigate the role of positron emission tomography (PET) and magnetic
resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with
locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by
evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before
and after NAC treatment.
Methods: Patients with LABC who were treated with NAC between November 2013 and
November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded.
Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35–
70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/
85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When
radiological skin involvement was assessed in relation to the final histopathological results, the
preNAC PET results and histopathological skin involvement were not significantly different; and
there was no difference between postNAC MRI and histopathological skin involvement.
Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement,
it might be possible to use these two radiological evaluation methods together to assess patient
suitability for skin-sparing mastectomy in selected patients.
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MALYA F. Ü. , KADIOGLU H., BEKTASOGLU H. K. , Gucin Z., YILDIZ S., GUZEL M., ERDOGAN E. B. , YUCEL S., ERSOY Y. E. , -The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.-, The Journal of international medical research, cilt.46, ss.626-636, 2018