Person: KADIOĞLU, HÜSEYİN
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Publication Metadata only Anxiety and depression levels and personality traits of mastalgia patients(2014-01-01) Yılmaz, Enver Demirel; Deveci, ERDEM; Kadıoğlu, HÜSEYİN; Gençe, Ali Görkem; Ünal, Özge; Koçer, Emel; KIRPINAR, İSMET; DEVECİ, ERDEM; KADIOĞLU, HÜSEYİN; KIRPINAR, İSMETPublication Metadata only The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats(2013-12-01T00:00:00Z) Bozkurt, SÜLEYMAN; GUNER, Ali; Kadioglu, HÜSEYİN; KECE, Can; REIS, Erhan; COSKUN, HALİL; BOZKURT, SÜLEYMAN; KADIOĞLU, HÜSEYİN; COŞKUN, HALILBackground/aims: To investigate the effects of different mechanisms on the development of pancreatitis after endoscopic retrograde cholangiopancreatography. Material and Methods: 40 male rats were randomly divided into four groups. After laparotomy, in Group 1, only duodenum was reached by a 24G cannula without performing any other procedure. In Groups 2, 3, and 4, biliopancreatic duct was cannulated transduodenally. Group 2 received no additional intervention after the cannulation. Group 3 received saline, whereas Group 4 received contrast agent into the duct. After a period of 24 hours, all rats were sacrificed. Laboratory tests for blood samples were performed and pancreatic tissue was also evaluated histopathologically. Results: Leukocyte, blood sugar, serum glutamic oxaloacetic transaminase, lactate dehydrogenase, amylase, C-reactive protein, and base excess parameters were evaluated. The values in Groups 2, 3, and 4 were found to be significantly higher than those in the control group, except for leukocyte count and base excess (p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683, respectively). Histopathological results demonstrated significant differences between the groups. Highest pathological damage scores were observed in Groups 3 and 4. Conclusion: Among different theories for the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, elevated intraductal hydrostatic pressure was observed to be the main underlying cause.Publication Metadata only p53 expression and relationship with MDM2 amplification in breast carcinomas(2016-04-01) Buyukpinarbasili, NUR; Gucin, ZÜHAL; Ersoy, YELİZ EMİNE; ILBAK, Ayca; Kadioglu, HÜSEYİN; Muslumanoglu, Mahmut; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINE; KADIOĞLU, HÜSEYİNCarcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.Publication Metadata only Role of F-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in diagnosis and management of pancreatic cancer; comparison with Multidetector Row Computed Tomography, Magnetic Resonance Imaging and Endoscopic Ultrasonography(2014-05-01) ERGUL, N.; GUNDOGAN, C.; TOZLU, M.; TOPRAK, HÜSEYİN; KADIOGLU, HÜSEYİN; Aydin, MEHMET; CERMIK, T. F.; TOPRAK, HÜSEYİN; KADIOĞLU, HÜSEYİN; AYDIN, MEHMETObjectives: We aimed to analyze the contribution of F-18-fluorodeoxyglucosepositron emission tomography/computed tomography (FDG PET/CT) imaging to the diagnosis and management of pancreatic cancer compared with multidetector row computed tomography (MDCT), magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS).Publication Metadata only Assessment of multifocality and axillary nodal involvement in early-stage breast cancer patients using 18F-FDG PET/CT compared to contrast-enhanced and diffusion-weighted magnetic resonance imaging and sentinel node biopsy(2015-08-01) ERGÜL, Nurhan; Kadioglu, HÜSEYİN; Yildiz, Seyma; YUCEL, Serap Baskaya; Gucin, ZÜHAL; Erdogan, EZGİ BAŞAK; Aydin, MEHMET; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; AYDIN, MEHMETBackground: Non-invasive evaluation of the extent of axillary nodal involvement in early-stage breast cancer (ESBC) patients and accurate assessment of multifocality are both challenging. Few reports have explored whether 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) might be more useful than other diagnostic methods in these contexts.Publication Open Access Management of Patients with Granulomatous Mastitis: Analysis of 31 Cases(2012-01-01T00:00:00Z) KAYAHAN, Munire; Kadioglu, HÜSEYİN; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİNBackground: Granulomatous mastitis is a benign recurrent disease. Accurate diagnosis is only by histopathology. Patients and Methods: 31 cases with histological diagnosis were retrospectively analyzed. Results: Mean follow-up was 42.4 months for recurrent and 27.8 months for non-recurrent cases. Etiology was tuberculosis in 1 case. 5 cases (16%) relapsed. 6 patients (19.3%) treated with abscess drainage healed completely, but 50% relapsed. Relapses were treated with excision or steroids. Steroid therapy was the initial treatment in 12 cases (38.7%), with 1 relapse (8.3%) which was treated in the same manner. 2 patients had incomplete response necessitating excision, and another 2 developed abscesses which were treated with steroids or excision after drainage. Surgical excision was preferred in 12 cases (38.7%) due to suspicion for carcinoma in 8 patients (25.8%) and/or low probability of poor cosmetic outcome. All healed without complication, and recurrence was observed in 1 case (8.3%) which was treated with re-excision. Conclusion: Both excision and steroid therapy had low and similar relapse rates, but excision was superior to steroid therapy in providing strict diagnosis with much faster healing and fewer complications. In refractory cases, and when deformity is inevitable, steroid therapy should be preferred.Publication Metadata only Primer Meme Lenfoması; Yineleyen Hastalık,(2012-05-01) KADIOGLU, HÜSEYİN; YUCEL, SERAP BASKAYA; GÜRAL, ZEYNEP; GÖZÜBÜYÜKOGLU, NURHAN; AKGÜN, ZÜLEYHA; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMAN; ERSOY, YELİZ EMİNE; SAGLAM, ESRA KAYTAN; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMANPublication Metadata only İNFLAMATUAR MEME KANSERİ ŞEKLİNDE PREZENTE OLAN MÜSİNÖZ MEME KANSERİ OLGUSU(2015-08-01) YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; KADIOĞLU, HÜSEYİNPublication Metadata only Results by treatment modalities in multifocal/multicentric breast cancer: Retrospective analysis of 162 patients.(2011-09-20T00:00:00Z) Kadioglu, HÜSEYİN; KAYAHAN, M.; ERSOY, Y. E.; MEMMI, NAİM; BOZKURT, SÜLEYMAN; CIPE, G.; MUSLUMANOGLU, M.; KADIOĞLU, HÜSEYİN; MEMMİ, NAİM; BOZKURT, SÜLEYMANPublication Metadata only Normal 0 21 Analysis of Safety and Effectiveness of Two Different Liquid-Filled Intragastric Balloon (Bioenterics (R) Vs Silimed (R))(2011-08-01T00:00:00Z) BOZKURT, SÜLEYMAN; COSKUN, HALİL; Kadioglu, HÜSEYİN; ERSOY, Y. E.; MUSLUMANOGLU, M.; BOZKURT, SÜLEYMAN; COŞKUN, HALIL; KADIOĞLU, HÜSEYİN