Publication:
Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats

No Thumbnail Available
Date
2014-02-01
Authors
Gecit, Ilhan
YUKSEL, Mehmet Bilgehan
Kavak, Servet
BASEL, Halil
Bektaş, Hava
Gumrukcuoglu, Hasan Ali
Meral, Ismail
Demir, Halit
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
The aim of this study is to evaluate the influences of short-term treatment with levosimendan (chemical formula: C14H12N6O) on oxidative stress and some trace element levels in renal tissues of healthy rats. A total of 20 male Wistar-albino rats were randomly divided into two groups, each consisting of 10 rats. Animals in the first group were not treated with levosimendan and served as control. Animals in the second group were injected intraperitoneally with 12 mu g/kg levosimendan and served as levosimendan group. Animals in both the groups were killed 3 days after the treatment, and their kidneys were harvested for the determination of tissue oxidant/antioxidant statues and trace element levels in renal tissues. The tissue malondialdehyde level was significantly (p < 0.001) lower in levosimendan group than in controls. The protective enzyme activities such as superoxide dismutase, catalase, and glutathione peroxidase and antioxidant glutathione level were significantly (p < 0.001) higher in levosimendan group than in controls. It was concluded that levosimendan reduced oxidative stress by avoiding lipid peroxidation and production of reactive oxygen species, and overactivating and/or increasing the protective antioxidant enzyme levels in renal tissues of rats. It is supposed that this experimental study provides beneficial data for clinicians in the management of renal tissue damage related to obstruction and/or ischemia.
Description
Keywords
Citation
Gecit I., Kavak S., YUKSEL M. B. , BASEL H., Bektaş H., Gumrukcuoglu H. A. , Meral I., Demir H., -Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats-, TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.30, ss.47-51, 2014
Page Views

0

File Downloads

0

Sustainable Development Goals