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dc.contributor.authorGecit, Ilhan
dc.contributor.authorYUKSEL, Mehmet Bilgehan
dc.contributor.authorKavak, Servet
dc.contributor.authorBASEL, Halil
dc.contributor.authorBektaş, Hava
dc.contributor.authorGumrukcuoglu, Hasan Ali
dc.contributor.authorMeral, Ismail
dc.contributor.authorDemir, Halit
dc.date.accessioned2019-10-05T21:05:11Z
dc.date.available2019-10-05T21:05:11Z
dc.date.issued2014-02-01
dc.identifier10.1080/15533174.2011.591302
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6456
dc.description.abstractThe aim of this study is to evaluate the influences of short-term treatment with levosimendan (chemical formula: C14H12N6O) on oxidative stress and some trace element levels in renal tissues of healthy rats. A total of 20 male Wistar-albino rats were randomly divided into two groups, each consisting of 10 rats. Animals in the first group were not treated with levosimendan and served as control. Animals in the second group were injected intraperitoneally with 12 mu g/kg levosimendan and served as levosimendan group. Animals in both the groups were killed 3 days after the treatment, and their kidneys were harvested for the determination of tissue oxidant/antioxidant statues and trace element levels in renal tissues. The tissue malondialdehyde level was significantly (p < 0.001) lower in levosimendan group than in controls. The protective enzyme activities such as superoxide dismutase, catalase, and glutathione peroxidase and antioxidant glutathione level were significantly (p < 0.001) higher in levosimendan group than in controls. It was concluded that levosimendan reduced oxidative stress by avoiding lipid peroxidation and production of reactive oxygen species, and overactivating and/or increasing the protective antioxidant enzyme levels in renal tissues of rats. It is supposed that this experimental study provides beneficial data for clinicians in the management of renal tissue damage related to obstruction and/or ischemia.
dc.language.isoen
dc.subjectGecit I., Kavak S., YUKSEL M. B. , BASEL H., Bektaş H., Gumrukcuoglu H. A. , Meral I., Demir H., -Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats-, TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.30, ss.47-51, 2014
dc.titleEffect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats
dc.typeArticle
local.avesis.response6332
local.article.journalnameSYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY
dc.identifier.wosWOS:000336842100006
dc.identifier.scopus84893562632
dc.identifier.doi10.1177/0748233712451773
dc.identifier.pubmed22722773
local.publication.isinternational1
dc.contributor.institutionauthorMERAL, İSMAİL


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