Person: MERAL, İSMAİL
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Publication Kardiyovasküler Hastalıklarda Biyotinidaz ve TCA Enzim Aktivitelerinin İncelenmesi(2023-07-09) Sarıkaya U.; Çimen Y. A.; Taşlıdere B.; Selek Ş.; Açıkgöz N.; Meral İ.; SARIKAYA, UFUK; ÇİMEN, YASİN ALİ; TAŞLIDERE, BAHADIR; SELEK, ŞAHABETTİN; AÇIKGÖZ, NUSRET; MERAL, İSMAİLPublication Effects of extracorporeal shock-wave lithotripsy directed at the parotid gland on oxidative stress parameters and some trace element levels in facial nerve of rats(2012-04-01T00:00:00Z) Kavak, Servet; Garca, M. Fatih; Gecit, Ilhan; Meral, Ismail; Cengiz, Nurettin; Demir, Halit; MERAL, İSMAİLIntroduction: This study was designed to assess the effect of extracorporeal shock-wave lithotripsy (ESWL) exposure of the parotid gland on oxidative stress and some trace element levels in the facial nerves of rats. Methods: Twelve male Wistar albino rats were divided into two groups, each consisting of 6 animals. The rats in the first group served as controls. The left parotid glands of animals in the second group were treated with 1000 18-kV shock waves while anesthetized with ketamine. The animals in both groups were euthanized 72 h after the ESWL treatment, and the right facial nerve was harvested for determination of oxidant/antioxidant status and trace element levels. Results: Lipid peroxidation product malondialdehyde (MDA) and antioxidant glutathione (GSH) levels increased, and the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), decreased in the facial nerves of ESWL-treated rats. The levels of iron, lead, manganese, and cobalt increased, and magnesium, cadmium, and copper levels decreased. Conclusions: ESWL treatment of the parotid gland may increase lipid peroxidation and decrease antioxidant enzyme activity in adjacent tissues such as the facial nerve. It also causes a decrease or increase in many mineral levels of the facial nerve, which is an undesirable condition for normal physiological function. Muscle Nerve, 2012Publication Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Effects of Angiotensin IV on Learning-Memory and Hippocampal Oxidative Stress in Diabetic Rats(2019-12-01T00:00:00Z) KILIÇ, Aysu; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Emine Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; BULUT, HURI; MERAL, İSMAİLPublication Role of Angiotensin TYpe I and II receptor Blockade in Ischemia/Reperfusion Injury of Isolated Rat Heart(2017-05-04) Kılıç, AYSU; ÜSTÜNOVA, SAVAŞ; Usta, Cansu; BULUT, HURİ; ÜYÜKLÜ, MEHMET; Demirci-Tansel, Cihan; MERAL, İSMAİL; Artumak, Elif; Gurevin-Gürel, Ebru; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; BULUT, HURI; ÜYÜKLÜ, MEHMET; MERAL, İSMAİLPublication Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis.(2019-02-01) BULUT, HURİ; ESREFOGLU, MUKADDES; BAYINDIR, NİHAN; Meral, I; CAGLAR, HİFA GÜLRU; SELEK, S; YUCE, BÜŞRA; DOGAN, NAREG; TELOGLU, EMİNE ŞEYDA; SONUC, G; YILDIZ, C; TIFTIK, E; SELEK, ŞAHABETTİN; EŞREFOĞLU, MUKADDES; MERAL, İSMAİL; BULUT, HURI; ÇAĞLAR, HİFA GÜLRU; TELOĞLU, EMİNE ŞEYDA; YÜCE, BÜŞRA; BAYINDIR, NİHANPublication Bir Üniversitenin Girişimsel Olmayan Araştırmalar Etik Kuruluna Yapılan Başvurularda Eksiklikler ve Sıklıkla Yapılan Hatalar(2019-08-01) Meral, İsmail; Aştı, Türkinaz; Soysal, Ömer; Yıldırım, Nuran; Özçelik, Semra; Aydın, Teoman; Akbaş, Fahri; Temel, Binnur; Özder, Aclan; Büyükpınarbaşılı, Nur; Dönmez, Nazmiye; Alkaya, Mustafa Fırat; MERAL, İSMAİL; AŞTI, TÜRKINAZ; SOYSAL, ÖMER; YILDIRIM, NURAN; ÖZÇELİK, SEMRA; AYDIN, TEOMAN; AKBAŞ, FAHRİ; TEMEL, BİNNUR; ÖZDER, ACLAN; BÜYÜKPINARBAŞILI, NUR; DÖNMEZ, NAZMİYEGirişimsel olmayan araştırmalarda, ilgili etik kurulun onayını almadan çalışmalara başlamak mümkün değildir. Dünya Sağlık Örgütü-nün kurallarına göre, gerekli tüm belgeleri içeren başvuru dosyası ilgili Etik Kurula eksiksiz sunulmalıdır. Araştırmacıların başvuru dosyasındaki belgeleri eksiksiz tamamlamadaki isteksizliği, Etik Kurulların çalışma sürecini yavaşlatmakta ve hatta Etik Kurul ile araştırmacılar arasında tartışmaya bile neden olabilmektedir. Bu nedenle bu çalışma, bir üniversitenin Girişimsel Olmayan Araştırmalar Etik Kuruluna gönderilen proje başvuru dosyalarındaki eksiklikleri ve en çok yapılan hataları göstermek ve araştırmacılar için bir rehber oluşturmak amacıyla yapıldı. 24 Mart 2016 ve 30 Haziran 2018 tarihleri arasında Girişimsel Olmayan Araştırmalar Etik Kurula gönderilen başvuru dosyaları ve kararları ilgili etik kurulun veri tabanından analiz edildi. Başvuru dosyalarının revizyonuna neden olan en önemli gerekçeler, projenin amacının ilgili referanslar eşliğinde yeterince açıklanamaması ve özellikle iyi yazılamamış yöntem kısmı gibi başvuru formundaki eksikliklerdi. Araştırmacıları proje başvuru dosyası hazırlarken en çok yapılan hatalar hakkında eğitmek, Üniversite Etik Kurullarının gözden geçirme sürecinin verimliliğini ve hızını artıracaktır.Publication FİZYOLOJİ(2019-02-01) MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞPublication Smoking-related Alterations in Serum Levels of Thyroid Hormones and Insulin in Female and Male Students(2015-09-01) Meral, Ismail; ARSLAN, Harun; Arslan, Ayşe; Him, Aydin; MERAL, İSMAİLContext Cigarette smoking has large-scale and complex effects on the endocrine system. Various studies related to cigarette smoking have provided differing results. Therefore, more research is needed to determine the effects on the body that are created by cigarette smoking.Publication The Prolidase Activity, Oxidative Stress, and Nitric Oxide Levels of Bladder Tissues with or Without Tumor in Patients with Bladder Cancer(2017-10-01) Eryılmaz, Recep; Kavak, Servet; Meral, Ismail; Demir, Halit; Pirincci, Necip; Gunes, Mustafa; Taken, Kerem; MERAL, İSMAİLThis study was designed to evaluate the malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) levels, and also prolidase, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) enzyme activities in malignant and benign cancers of bladder tissue. A total of 59 patients admitted to our clinic due to microscopic or macroscopic haematuria, were prospectively included in the study. Because of some reasons (no request to participate in the study, the inability to reach, other malignancies, alcohol consumption, metabolic disease), eight patients were excluded from study. Of the 51 patients, 25 were bladder tumor patients, and 26 were patients without cancers. The bladder tissue samples were obtained from all patients under anesthesia (spinal, epidural or general) for the measurement of MDA, GSH and NO levels, and prolidase, GSH-Px and SOD enzyme activities. Among the patients with bladder cancers, 7 patients were females and 18 patients were males, with an average age of 68.4 +/- 2.49. Among patients without tumors, 6 patients were females and 20 patients were males, with an average age of 58 +/- 2.05. In patients with bladder tumors, the oxidants (MDA, NO, prolidase) were higher, and the antioxidants (SOD, GSH, GSH-Px) were lower than those in patients without tumors. It was concluded that the oxygen free radicals play a role in the etiology of bladder cancers similar to many other tumors and inflammatory conditions. Therefore, we assume that antioxidants may provide benefits in the prevention and treatment of bladder cancer.