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The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort

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Date
2016-07-01
Author
Hanagasi, Hasmet
Gezen-Ak, Duygu
Dursun, Erdinc
Bilgic, Basar
Ertan, Turan
Uysal, Omer
Yilmazer, Selma
Eker, Engin
Emre, Murat
Gurvit, Hakan
Alaylioglu, Merve
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Type
Article
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Abstract
Previous studies have demonstrated that clusterin (CLU), which is also known as apolipoprotein J, is involved in the pathogenesis of Alzheimer disease (AD). In this study, we investigated the association between rs2279590, rs11136000, and rs9331888 single-nucleotide polymorphisms (SNPs) in CLU and apolipoprotein E (APOE) genotypes in a cohort of Turkish patients with late-onset AD (LOAD). There were 183 patients with LOAD and 154 healthy controls included in the study. The CLU and APOE polymorphisms were genotyped using the LightSNiP assay. The GG genotype of rs9331888 was significantly more frequent in patients with LOAD. The CC genotype of the SNP was significantly more frequent in controls. The rs9331888 GG genotype in patients and the CC genotype in controls were significantly higher in non-4 allele carriers of APOE. The haplotype analysis showed the CLU GCG haplotype was a risk haplotype. Our findings indicate the rs9331888 SNP of CLU is associated with LOAD independent of APOE.
Subject
Alaylioglu M., Gezen-Ak D., Dursun E., Bilgic B., Hanagasi H., Ertan T., Gurvit H., Emre M., Eker E., Uysal O., et al., -The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort-, JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, cilt.29, ss.221-226, 2016
URI
https://hdl.handle.net/20.500.12645/6125
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS