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Effect of magnesium supplementation on blood rheology in NOS inhibition-induced hypertension model

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Date
2016-01-01
Author
Özyurt, Dilek
Ulker, Pinar
Uyuklu, MEHMET
CENGİZ, MELİKE
YARAŞ, NAZMİ
ÖZEN, NUR
Aslan, Mutay
BASRALI, FİLİZ
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Type
Article
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Abstract
This study investigated the effects of magnesium on blood rheological properties and blood pressure in nitric oxide synthase (NOS) inhibition-induced hypertension model. Hypertension was induced by oral administration of the nonselective NOS inhibitor N-nitro-L-arginine methyl ester (L-NAME, 25 mg/kg/day) for 6 weeks and systolic blood pressure was measured by the tail-cuff method. The groups receiving magnesium supplementation were fed with rat chow containing 0.8% magnesium oxide during the experiment. At the end of experiment, blood samples were obtained from abdominal aorta, using ether anesthesia. Plasma and erythrocyte magnesium levels were determined by the atomic absorption spectrometer. RBC deformability and aggregation were determined by rotational ektacytometry. Plasma fibrinogen concentration was evaluated by ELISA. Whole blood and plasma viscosities were determined by viscometer and intracellular free Ca++ level was measured by using spectroflurometric method. Blood pressure was elevated in hypertensive groups and suppressed by magnesium therapy. Plasma viscosity and RBC aggregation were found to be higher in hypertensive rats than control animals and these parameters significantly decreased in magnesium supplemented hypertensive animals. Other measurements were not different between experimental groups. These results confirm that blood pressure, plasma viscosity and RBC aggregation increased in NOS inhibition-induced hypertension model and oral magnesium supplementation improved these parameters.
Subject
CENGİZ M., Ulker P., Uyuklu M., YARAŞ N., ÖZEN N., Aslan M., Özyurt D., BASRALI F., -Effect of magnesium supplementation on blood rheology in NOS inhibition-induced hypertension model-, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.63, ss.57-67, 2016
URI
https://hdl.handle.net/20.500.12645/5323
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  • Yayınlar - Eserler [9983]

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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS