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Effect of magnesium supplementation on blood rheology in NOS inhibition-induced hypertension model

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dc.contributor.authorCENGİZ, MELİKE
dc.contributor.authorUlker, Pinar
dc.contributor.authorUyuklu, MEHMET
dc.contributor.authorYARAŞ, NAZMİ
dc.contributor.authorÖZEN, NUR
dc.contributor.authorAslan, Mutay
dc.contributor.authorÖzyurt, Dilek
dc.contributor.authorBASRALI, FİLİZ
dc.contributor.institutionauthorÜYÜKLÜ, MEHMET
dc.date.accessioned2019-10-05T15:03:06Z
dc.date.available2019-10-05T15:03:06Z
dc.date.issued2016-01-01
dc.description.abstractThis study investigated the effects of magnesium on blood rheological properties and blood pressure in nitric oxide synthase (NOS) inhibition-induced hypertension model. Hypertension was induced by oral administration of the nonselective NOS inhibitor N-nitro-L-arginine methyl ester (L-NAME, 25 mg/kg/day) for 6 weeks and systolic blood pressure was measured by the tail-cuff method. The groups receiving magnesium supplementation were fed with rat chow containing 0.8% magnesium oxide during the experiment. At the end of experiment, blood samples were obtained from abdominal aorta, using ether anesthesia. Plasma and erythrocyte magnesium levels were determined by the atomic absorption spectrometer. RBC deformability and aggregation were determined by rotational ektacytometry. Plasma fibrinogen concentration was evaluated by ELISA. Whole blood and plasma viscosities were determined by viscometer and intracellular free Ca++ level was measured by using spectroflurometric method. Blood pressure was elevated in hypertensive groups and suppressed by magnesium therapy. Plasma viscosity and RBC aggregation were found to be higher in hypertensive rats than control animals and these parameters significantly decreased in magnesium supplemented hypertensive animals. Other measurements were not different between experimental groups. These results confirm that blood pressure, plasma viscosity and RBC aggregation increased in NOS inhibition-induced hypertension model and oral magnesium supplementation improved these parameters.
dc.identifier10.1556/030.63.2016.1.3
dc.identifier.citationCENGİZ M., Ulker P., Uyuklu M., YARAŞ N., ÖZEN N., Aslan M., Özyurt D., BASRALI F., -Effect of magnesium supplementation on blood rheology in NOS inhibition-induced hypertension model-, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.63, ss.57-67, 2016
dc.identifier.doi10.3233/ch-152032
dc.identifier.pubmed26890104
dc.identifier.scopus84977269463
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5323
dc.identifier.wosWOS:000380237400006
dc.language.isoen
dc.titleEffect of magnesium supplementation on blood rheology in NOS inhibition-induced hypertension model
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
local.avesis.id82df4e22-1032-4838-b1fd-970a50431783
local.avesis.response5193
local.publication.isinternational1
relation.isAuthorOfPublicationbc1199b5-be6a-43cc-9b25-7e47066119cc
relation.isAuthorOfPublication.latestForDiscoverybc1199b5-be6a-43cc-9b25-7e47066119cc
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