Parathyroid Allotransplant With a New Technique: A Prospective Clinical Trial.
Abstract
Objectives: Parathyroid allotransplant is a valuable
alternative in treating permanent hypoparathyroidism. However, it is a difficult process that
requires several trained staff and advanced laboratory
equipment, which makes the costs high. Here,
we identify a new parathyroid allotransplant
technique.
Materials and Methods: After obtaining informed
consent from patients, parathyroid cell suspensions
obtained from 4 donors who had undergone a
subtotal parathyroidectomy owing to chronic renal
failure were transplanted in 10 patients with
permanent hypoparathyroidism after short-term cell
cultivation. Prednisolone were used as immunosuppressant for the first 10 days and discontinued
thereafter.
Results: Allograft function was observed in 7 patients
(70%) at a mean follow-up of 12 months. Daily oral
calcium and vitamin D supplementations discontinued
totally in 7 patients. No major or minor complication
was observed.
Conclusions: Our technique is simple, fast, and
has a low cost, with a 70% success rate at a mean
follow-up of 12 months. It requires few staff, minimal
equipment, and short-term immunosuppressant use
for main tenance. The technical developments of
parathyroid allotransplant, as mentioned in this
study, may be important in treating permanent
hypoparathyroidism
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