Publication: Origami with ABC Triblock Terpolymers Based on Glycopolymers: Creation of Virus-Like Morphologies
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Date
2015-05-01
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Dag, AYDAN
ZHAO, Jiacheng
STENZEL, Martina H.
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Abstract
Morphologies, that resemble viruses, were created using a single ABC triblock terpolymer poly(2-acryloylethyl-alpha-D-mannopyranoside)-b-poly(n-butyl acrylate)-b-poly(4-vinylpyridine) (PAcManA(70)-b-PBA(369)-b-PVP370). Morphologies ranging from flower-like micelles, cylindrical micelles, raspberry-like morphologies to nanocaterpillars were obtained by adjusting the pH value during the self-assembly process. The resulting nanoparticles had an abundance of mannose on the surface, which were recognized by the mannose receptors of RAW264.7, a macrophage cell line that can be used as a model for virus entry.
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Dag A., ZHAO J., STENZEL M. H. , -Origami with ABC Triblock Terpolymers Based on Glycopolymers: Creation of Virus-Like Morphologies-, ACS MACRO LETTERS, cilt.4, ss.579-583, 2015