Person: DAĞ, AYDAN
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Publication Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives(2017-02-15) KURT, Belma Zengin; Gazioglu, IŞIL; Dag, AYDAN; Salmas, Ramin Ekhteiari; Kayik, Gulru; Durdagi, Serdar; Sonmez, Fatih; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; DAĞ, AYDANNew thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was found to be the most potent AChE inhibitor with IC50 values of 2.22 mu M, and 5-isopropyl-2-methylphenyl (4-fluorophenyl)carbamate (30) exhibited the strongest inhibition against BuChE with IC50 value of 0.02 mu M. Additionally, the result of H4IIE hepatoma cell toxicity assay for compounds 18, 20, 29, 30 and 35 showed negligible cell death at 0.07-10 mu M. Moreover in order to better understand the inhibitory profiles of these molecules, molecular modeling studies were applied. Binding poses of studied compounds at the binding pockets of AChE and BuChE targets were determined. Predicted binding energies of these compounds as well as structural and dynamical profiles of molecules at the target sites were estimated using induced fit docking (IFD) algorithms and post-processing molecular dynamics (MD) simulations methods (i.e., Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) approaches). (C) 2016 Elsevier Ltd. All rights reserved.Publication Hedefli ilaç/gen içeren biyonanoprobların hazırlanması ve tedavi edici potansiyellerinin araştırılması(2021-12-02T00:00:00Z) Atasoy, Sezen; Göncü, Beyza Servet; Erdem, Gülsah; Omurtag Özgen, Pınar Sinem; Dağ, Aydan; ATASOY, SEZEN; GÖNCÜ, BEYZA SERVET; DAĞ, AYDANPublication Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine(2014-01-01T00:00:00Z) Bahadori, Fatemeh; Dag, Aydan; Durmaz, Hakan; Cakir, Nese; ONYUKSEL, Hayat; Tunca, Ümit; Topcu, Gulacti; Hızal, Gürkan; BAHADORİ, FATEMEH; DAĞ, AYDAN; TOPÇU, GÜLAÇTITwo amphiphilic block copolymers using hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)(4) type star polymer [(PCL-b-PEG)(4)] and the other one is a Y-shaped PEG-(PCL)(2). A star-shaped polymer (PCL-b-PEG)(4) was prepared by ring-opening polymerization (ROP) of epsilon-caprolactone continued by click reaction of (PCL-azide)(4) and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL)(2) block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of epsilon-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.Publication An easy way to the preparation of multi-miktoarm star block copolymers via sequential double click reactions(2010-07-01T00:00:00Z) Dag, Aydan; Durmaz, Hakan; Kirmizi, Volkan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDANAs a new synthetic route, we here employed sequential double click reactions involving azide-alkyne and Diels-Alder reactions for the preparation of multi-miktoarm star block copolymers by using the arm-first approach.Publication Sythesis of Glycopeptide Nanoparticles and Investigation of Their Efficacy in Cancer Therapy(2017-10-02) Dağ, Aydan; DAĞ, AYDAN; ATASOY, SEZENPublication Preclinical studies evaluating the therapeutic efficacy of novel natural compound olean-12-en-28-ol, 3β pentacosanoate for multiple sclerosis(2022-09-26) Şenol H.; Özgün-Acar Ö.; Dağ A.; Eken A.; Acar B.; Aktaş Pepe N.; Güner H.; Aykut Z. G.; Çevik Kaplan S.; Ayaz Güner Ş.; et al.; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Synthesis and Characterization of Paclitaxel-loaded pH-sensitive Glycopolymeric Micelles(2023-09-14) Sancaklı B.; Gencoglu Katmerlikaya T.; Cetin Ersen B.; Omurtag Özgen P. S.; Dağ A.; DAĞ, AYDANPublication Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy(2014-01-01) ZHAO, Jiacheng; BABIUCH, Krzysztof; Lu, Hongxu; Dag, AYDAN; GOTTSCHALDT, Michael; STENZEL, Martina H.; DAĞ, AYDANFructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.Publication Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy(2024-03-01) Gençoğlu Katmerlikaya T.; Ersen B. C.; Dağ A.; Sancakli B.; Ozgen P. S. O.; Yalcin E. K.; Avci B.; DAĞ, AYDANPublication pH Sensitive Targeted Dual Drug Delivery System for Osteosarcoma(2023-09-12) Mutlu I.; Gencoglu-Katmerlikaya T.; Cetin-Ersen B.; Atasoy S.; Dağ A.; ATASOY, SEZEN; DAĞ, AYDAN