Brain Diffusion Changes in Obstructive Sleep Apnoea Syndrome
Date
2013-01-01Author
KILICARSLAN, RukiyeSharifov, RASUL
Aralasmak, AYŞE
Bayram, MEHMET
Kart, Levent
Akkoyunlu, MUHAMMED EMİN
Alkan, ALPAY
Advisor
Type
Metadata
Show full item recordAbstract
Background: Obstructive sleep apnoea syndrome (OSAS) is
a disorder characterized by repeated apnoeic episodes during sleep. Neurocognitive changes secondary to OSAS are
likely to occur due to hypoxia in certain brain locations. Advances in magnetic resonance imaging technology, such as
diffusion-weighted imaging (DWI), enable non-invasive and
accurate identification of OSAS-induced changes. Objective: We aimed to use DWI to investigate changes in the
brain secondary to hypoxia in OSAS. Methods: Eighty-eight
patients underwent polysomnography and were classified
as non-OSAS, mild-moderate OSAS and severe OSAS sufferers. DWI was used to evaluate 14 areas of the brain, and apparent diffusion coefficients (ADCs) were calculated. We investigated whether there were differences in the ADC values
in specific areas of the brain between the non-OSAS and
OSAS patients. Results: We measured the ADC values of the
68 newly diagnosed OSAS patients (21 mild, 15 moderate
and 32 severe) and of 20 healthy controls. There were significant increases in the ADC values in the hippocampus,
amygdala and putamen in OSAS patients. Compared to thenon-OSAS subjects, the ADC values of the putamen in severe
OSAS patients, those of the hippocampus in moderate or severe OSAS patients and those of the amygdala in moderate
OSAS patients were significantly increased. A negative correlation between the lowest oxygen saturation during sleep
and the ADC values of the hippocampus and amygdala was
found. Conclusions: Increased ADC levels in the hippocampus, amygdala and putamen in OSAS patients indicate hypoxia and likely cause vasogenic oedema in specific regions
of the brain.
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