Person: ARALAŞMAK, AYŞE
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Publication The Effect of Obesity on Brain Diffusion Alteration in Patients with Obstructive Sleep Apnea(2014-01-01) KILICARSLAN, Rukiye; Alkan, ALPAY; Sharifov, RASUL; Akkoyunlu, MUHAMMED EMİN; Aralasmak, AYŞE; KOCER, Abdulkadir; KART, Levent; ALKAN, ALPAY; SHARIFOV, RASUL; AKKOYUNLU, MUHAMMED EMİN; ARALAŞMAK, AYŞEPurpose: We investigated diffusion alterations in specific regions of the brain in morbid obese, obese, and nonobese OSA patients and searched whether there is a correlation between BMI and ADC values. Materials and methods: DWIs of 65 patients with OSA were evaluated. The patients were classified according to BMI as morbid obese (n = 16), obese (n = 27), and nonobese (control, n = 22) groups. ADC measurements were performed from 24 different regions of the brain in each patient. The relationship of BMI with ADC values was searched. Results: The ADC values in hypothalamus, insular cortex, parietal cortex, caudate nucleus, frontal white matter, and posterior limb of internal capsule were all increased in obese patients (n = 43) compared to control group. The ADC values of midbrain, hypothalamus, orbitofrontal cortex, and parietal cortex were significantly increased in morbid obese compared to obese patients. In obese patients, the degree of BMI was positively correlated with ADC values of orbitofrontal cortex, parietal cortex, and hypothalamus. Conclusion: We observed increasing brain vasogenic edema with increasing BMI, suggesting that the main reason of brain diffusion alteration in patients with OSA could be obesity related.Publication Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers.(2018-11-17) SEYITHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHIM SA; Dündar, TOLGA TURAN; KITIŞ, SERKAN; ARALAŞMAK, AYŞE; Gündağ, Papaker; SASANI, H; SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHıM SA; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; ARALAŞMAK, AYŞE; GUNDAG, MELİHABackground: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. Material/Methods: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). Results: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. Conclusions: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposurePublication Comparison of Delay-Sensitive and Delay-Insensitive Computed Tomography Perfusion Methods in Acute Ischemic Stroke and Their Variability According to Location of Critical Vascular Stenosis(2018-01-01) KARAALIOGLU, Banu; Aralasmak, AYŞE; Toprak, HÜSEYİN; Kolukisa, MEHMET; Uysal, Omer; Yildiz, Seyma; Ozdemir, HÜSEYİN; Alkan, ALPAY; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; KOLUKISA, MEHMET; UYSAL, ÖMER; YILDIZ, ŞEYMA; ÖZDEMİR, HÜSEYIN; ALKAN, ALPAYObjective The aim of this study was to evaluate visual and quantitative differences of delay-sensitive (singular value deconvolution [SVD]) and delay-insensitive (SVD+) computed tomography perfusion (CTP) postprocessing methods in acute ischemic stroke patients and their variability according to location of critical stenosis.Publication Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension(2019-05-01) Yilmaz, TEMEL FATİH; Aralasmak, AYŞE; Toprak, HÜSEYİN; MEHDI, Elnur; KOCAMAN, Gulsen; Kurtcan, SERPİL; Kaya, MEHMET ONUR; Alkan, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; KURTCAN, SERPİL; KAYA, MEHMET ONUR; ALKAN, ALPAYPurpose To search for CSF dynamics of idiopathic intracranial hypertension (IIH) and communicating hydrocephalus and any correlation between MRI findings, CSF metrics and CSF opening pressure in IIH.Publication Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma(2016-12-01) KURTCAN, SERPİL; Alkan, ALPAY; Kilicarslan, R.; BAKAN, A. A.; TOPRAK, HÜSEYİN; ARALASMAK, AYŞE; AKSOY, FEYZA MÜBERRA; Kocer, A.; KURTCAN, SERPİL; ALKAN, ALPAY; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞEIn the studies concerning the pathology of the auditory pathway in the vestibulocochlear system, few use advanced neuroimaging applications of magnetic resonance imaging (MRI) such as diffusion tensor imaging (DTI). Those who did use reported DTI changes only at the lateral lemniscus and inferior colliculus level. The aim of our study was to determine diffusion changes in the bilateral auditory pathways of subjects with unilateral acoustic neuroma (AN) and compare them with healthy controls.Publication PATIENT WITH INTERMITTENT POSTURE ABNORMALITY: AN ALEXANDER DISEASE CASE REPORT(2019-06-01T00:00:00Z) İÇAĞASIOĞLU, Dilara Füsun; İŞCAN, AKIN; ARALAŞMAK, Ayşe; NURSOY, HATİCE; YEŞİL, Gözde; AYDIN, NİHAL; Sahin, Seyma Sonmez; İÇAĞASIOĞLU, DİLARA FÜSUN; İŞCAN, AKIN; ARALAŞMAK, AYŞE; NURSOY, HATİCE; YEŞİL, GÖZDE; AYDIN, NİHALPublication Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP inResidue Evaluation of Treated Intracranial Aneurysms(2017-11-10T00:00:00Z) DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; Toprak, Huseyin; Kitiş, Serkan; Ozek, Erdinc; UYSAL, ÖMER; ALKAN, ALPAY; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; UYSAL, ÖMER; ALKAN, ALPAYPublication Magnetic Resonance Spectroscopy Features of Heschl-s Gyri in Patients with Unilateral Acoustic Neuroma: Preliminary Study(2014-12-01) KILICARSLAN, Rukiye; Alkan, ALPAY; Aralasmak, AYŞE; AKSOY, Fadlullah; Toprak, HÜSEYİN; YETIS, Huseyin; Ozturan, ORHAN; ALKAN, ALPAY; ARALAŞMAK, AYŞE; AKSOY, FADLULLAH; ÖZTURAN, ORHANRationale and Objectives: To evaluate neurochemical alterations in Heschl-s gyri and determine the most affected side in case of Unilateral acoustic neuroma using magnetic resonance spectroscopy (MRS).Publication Baş boyun kitlelerinde MR perfüzyon bulguları(2013-05-25) ARALAŞMAK, AYŞE; YETİŞ, HÜSEYİN; YILDIZ, ŞEYMA; MERİÇ HAFIZ, AYŞENUR; BÜYÜKPINARBAŞILI, NUR; TOPRAK, HÜSEYİN; ALKAN, ALPAY; ARALAŞMAK, AYŞE; YILDIZ, ŞEYMA; MERİÇ HAFIZ, AYŞENUR; BÜYÜKPINARBAŞILI, NUR; TOPRAK, HÜSEYİN; ALKAN, ALPAYPublication MRI and MR Spectroscopy Features of Heat Stroke: A Case Report(2018-07-01) Yilmaz, TEMEL FATİH; Aralasmak, AYŞE; Toprak, HÜSEYİN; GULER, Serhat; Tüzün, Umit; Alkan, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; ALKAN, ALPAYHeat stroke is the outcome of over heat stress that results in multiorgan dysfunction with a tendency for central nervous system damage. Brain is very sensitive to hyperthermia, especially the cerebellum that has selective vulnerability to heat stroke. There is complex interaction between heat cytotoxicity, coagulation disorder, cytotoxine - mediated systemic inflammatory response causing multiorgan failure, metabolic derangement, and circulatory insufficiency. We reviewed the literature and discussed brain MRI and MR spectroscopy findings of heat stroke, detailed the pathophysiology underlying brain involvement and proposed excitotoxic injury as an alternative mechanism of brain damage in heat stroke.