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Brain Diffusion Changes in Obstructive Sleep Apnoea Syndrome

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dc.contributor.authorAkkoyunlu, MUHAMMED EMİN
dc.contributor.authorKart, Levent
dc.contributor.authorKILICARSLAN, Rukiye
dc.contributor.authorBayram, MEHMET
dc.contributor.authorAralasmak, AYŞE
dc.contributor.authorSharifov, RASUL
dc.contributor.authorAlkan, ALPAY
dc.contributor.institutionauthorAKKOYUNLU, MUHAMMED EMİN
dc.contributor.institutionauthorBAYRAM, MEHMET
dc.contributor.institutionauthorARALAŞMAK, AYŞE
dc.contributor.institutionauthorSHARIFOV, RASUL
dc.contributor.institutionauthorALKAN, ALPAY
dc.date.accessioned2019-10-05T14:37:55Z
dc.date.available2019-10-05T14:37:55Z
dc.date.issued2013-01-01
dc.description.abstractBackground: Obstructive sleep apnoea syndrome (OSAS) is a disorder characterized by repeated apnoeic episodes during sleep. Neurocognitive changes secondary to OSAS are likely to occur due to hypoxia in certain brain locations. Advances in magnetic resonance imaging technology, such as diffusion-weighted imaging (DWI), enable non-invasive and accurate identification of OSAS-induced changes. Objective: We aimed to use DWI to investigate changes in the brain secondary to hypoxia in OSAS. Methods: Eighty-eight patients underwent polysomnography and were classified as non-OSAS, mild-moderate OSAS and severe OSAS sufferers. DWI was used to evaluate 14 areas of the brain, and apparent diffusion coefficients (ADCs) were calculated. We investigated whether there were differences in the ADC values in specific areas of the brain between the non-OSAS and OSAS patients. Results: We measured the ADC values of the 68 newly diagnosed OSAS patients (21 mild, 15 moderate and 32 severe) and of 20 healthy controls. There were significant increases in the ADC values in the hippocampus, amygdala and putamen in OSAS patients. Compared to thenon-OSAS subjects, the ADC values of the putamen in severe OSAS patients, those of the hippocampus in moderate or severe OSAS patients and those of the amygdala in moderate OSAS patients were significantly increased. A negative correlation between the lowest oxygen saturation during sleep and the ADC values of the hippocampus and amygdala was found. Conclusions: Increased ADC levels in the hippocampus, amygdala and putamen in OSAS patients indicate hypoxia and likely cause vasogenic oedema in specific regions of the brain.en
dc.identifier10.1007/s11255-014-0838-3
dc.identifier.citationAkkoyunlu M. E. , Kart L., KILICARSLAN R., Bayram M., Aralasmak A., Sharifov R., Alkan A., -Brain Diffusion Changes in Obstructive Sleep Apnoea Syndrome-, RESPIRATION, cilt.86, ss.414-420, 2013
dc.identifier.pubmed23751445
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4332
dc.identifier.urihttps://www.karger.com/Article/FullText/350461
dc.identifier.wosWOS:000329046200009
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectSleep Apnoea Syndrome
dc.titleBrain Diffusion Changes in Obstructive Sleep Apnoea Syndrome
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL UROLOGY AND NEPHROLOGY
local.avesis.id699455a2-7693-440c-b797-cca3e1363e2a
local.avesis.response4202
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