• Home
  • About
  • Policies
  • Contact
    • English
    • Türkçe
  • English 
    • English
    • Türkçe
  • Login
Advanced Search
View Item 
  •   Home
  • Tüm Akademik Yayınlar
  • Yayınlar - Eserler
  • View Item
  •   Home
  • Tüm Akademik Yayınlar
  • Yayınlar - Eserler
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Light-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells

Thumbnail
Date
2015-08-01
Author
VITUCCI, Dylan
SAVE, Maud
Lu, Hongxu
PEARSON, Samuel
KHINE, Yee Yee
Dag, AYDAN
STENZEL, Martina H.
BILLON, Laurent
Advisor
Type
Article
Metadata
Show full item record
Abstract
Light-responsive glycopolymer micelles were produced by the self-assembly of amphiphilic block copolymers containing azobenzene and beta-galactose units. These well-defined block copolymers were synthesised firstly by the RAFT polymerisation of an azobenzene methacrylate monomer (AzoMA) to produce two short azobenzene macroRAFT agents containing 7 and 15 monomer units. Chain extension with a second block of similar to 150 or similar to 250 sugar units comprising of a protected beta-galactose monomer (beta-AcGalEtMA) generated four block copolymers, which were converted to amphiphilic structures by deprotection of the acetyl groups on the sugar units. Micelles with well-defined sizes of 26-50 nm were produced by self-assembly in water. The azobenzene units isomerised very rapidly to their more polar cis isomers under UV irradiation, reaching the photostationary state within 2 min, with reversion to the trans state taking several hours in the dark. This transition to the more polar cis state is an important criteria for aiding expulsion of a hydrophobic payload. In cell studies, unloaded micelles showed low cytotoxicity, and micelles loaded with the model hydrophobic compound Nile red demonstrated high cellular uptake in human melanoma A375 cells, demonstrating their suitability as a potential drug delivery system for melanoma. (C) 2015 Elsevier Ltd. All rights reserved.
Subject
PEARSON S., VITUCCI D., KHINE Y. Y. , Dag A., Lu H., SAVE M., BILLON L., STENZEL M. H. , -Light-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells-, EUROPEAN POLYMER JOURNAL, cilt.69, ss.616-627, 2015
URI
https://hdl.handle.net/20.500.12645/4301
Collections
  • Eczacılık Fakültesi [429]
  • Scopus İndeksli Yayınlar Koleksiyonu [4450]
  • WoS İndeksli Yayınlar Koleksiyonu [5147]
  • Yayınlar - Eserler [9994]

BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS


Bezmialem Kütüphane


OpenAccess@BVU validated by OpenAIRE

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageRightsby AdvisorThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageRightsby Advisor

My Account

LoginRegister

BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS