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Correlation between the mechanical and histological properties of liver tissue

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Date
2014-01-01
Author
Ayyildiz, Mehmet
Yarpuzlu, Berkay
Tok, OLGU ENİS
Basdogan, Cagatay
Aktas, Ranan Gulhan
Advisor
Type
Article
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Abstract
In order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological properties of liver is necessary. We suggest that this relation can only be established truly if the changes in the states of those properties are investigated dynamically as a function of post mortem time. In this regard, we first perform mechanical characterization experiments on three bovine livers to investigate the changes in gross mechanical properties (stiffness, viscosity, and fracture toughness) for the preservation periods of 5, 11, 17, 29, 41 and 53 h after harvesting. Then, the histological examination is performed on the samples taken from the same livers to investigate the changes in apoptotic cell count, collagen accumulation, sinusoidal dilatation, and glycogen deposition as a function of the same preservation periods. Finally, the correlation between the mechanical and histological properties is investigated via the Spearman-s Rank-Order Correlation method. The results of our study show that stiffness, viscosity, and fracture toughness of bovine liver increase as the preservation period is increased. These macroscopic changes are very strongly correlated with the increase in collagen accumulation and decrease in deposited glycogen level at the microscopic level. Also, we observe that the largest changes in mechanical and histological properties occur after the first 11-17 h of preservation. (C) 2013 Elsevier Ltd. All rights reserved.
Subject
Yarpuzlu B., Ayyildiz M., Tok O. E. , Aktas R. G. , Basdogan C., -Correlation between the mechanical and histological properties of liver tissue-, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, cilt.29, ss.403-416, 2014
URI
https://hdl.handle.net/20.500.12645/3736
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  • Scopus İndeksli Yayınlar Koleksiyonu [4451]
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  • Yayınlar - Eserler [9983]

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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS