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  • PublicationMetadata only
    Speech auditory brainstem response in audiological practice: a systematic review
    (2023-01-01) Başöz Behmen M.; Güner N.; Kuru E.; Bal N.; Gedik Toker Ö.; BAŞÖZ, MELIHA; KURU, ELIF; GEDİK, ÖZGE
    Background: Speech-ABR is an auditory brainstem response that evaluates the integrity of the temporal and spectral coding of speech in the upper levels of the brainstem. It reflects the acoustic properties of the stimulus used and consists of seven major waves. Waves V and A represent the onset of the response; wave C transition region; D, E, and F waves periodic region (frequency following response); and wave O reflects the offset of the response.PurposeThe aim of this study is to evaluate the clinical availability of the speech-ABR procedure through a literature review.MethodsLiterature search was conducted in Pubmed, Google Scholar, Scopus and Science Direct databases. Clinical studies of the last 15 years have been included in this review and 60 articles have been reviewed.ResultsAs a result of the articles reviewed, it was seen that most of the studies on speech ABR were conducted with children and young people and generally focused on latency analysis measurements. Most used stimulus is the /da/ syllable.ConclusionsSpeech ABR can objectively measure the auditory cues important for speech recognition and has many clini- cal applications. It can be used as a biomarker for auditory processing disorders, learning disorders, dyslexia, otitis media, hearing loss, language disorders and phonological disorders. S-ABR is an effective procedure that can be used in speech and language evaluations in people with hearing aids or cochlear implant. It may also be of benefit to the aging auditory system\"s ability to encode temporal cues.
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    Evaluation of Anxiety in Turkish Parents of Newborns with Cleft Palate with or Without Cleft Lip
    © 2023, American Cleft Palate Craniofacial Association.Objective: (1) To compare anxiety between parents of newborns with cleft lip and palate (CLP), isolated cleft palate (CP), and healthy newborns and (2) to evaluate anxiety between parental dyads within these groups. Design: A cross-sectional study. Setting: University Hospital. Participants: Surveys were completed by 20 mothers and 20 fathers of newborns with CLP, 21 mothers and 21 fathers of newborns with CP, and 23 mothers and 23 fathers of healthy newborns (controls). Main Outcome Measure: The State-Trait Anxiety Inventory (STAI) assessed parental anxiety. Mothers of newborns with a cleft reported on concerns regarding cleft-related issues and facial appearance. Results: State and trait anxiety were generally in the moderate range for parents of newborns with a cleft, while control parents had low state anxiety and moderate trait anxiety. Mothers of newborns with CP and CLP had significantly higher state and trait anxiety levels than control mothers (p <.05). Fathers of newborns with CLP had a higher state anxiety level than control fathers. When maternal and paternal anxiety was compared within the groups, only trait anxiety scores were significantly higher in mothers of newborns with CLP than that of fathers (p <.05). More than half of mothers of newborns with a cleft were concerned about their newborn\"s feeding, speech, and palate. Conclusions: Parents of children with a cleft may need psychological support in the early postnatal period. It is important for neonatal cleft team providers to help reduce parental anxiety and educate families about cleft care, with a focus on feeding.
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    Comparison of Cytokine Hemadsorption as an Immunomodulator Therapy in COVID-19 Patients with and without Bacterial Sepsis
    (2022-10-01) Koc S.; Hanikoglu F.; Dokur M.; Polat Y.; Celebi S.; Koc S. G.; Kupeli I.; UYSAL H.; UYSAL, HARUN
    © 2022 Verlag Klinisches Labor GmbH. All rights reserved.Background: In this retrospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in COVID-19 ICU patients with or without sepsis. Methods: The levels of PCT, CRP, and ferritin were determined as indicators of infection/sepsis; the levels of interleukins (IL-6, IL-8 and IL-10, and TNF-α) were determined as indicators of cytokine storm were compared. APACHE score, SOFA score, and mortality rates were compared for the progression of the disease in 23 COVID-19 patients. Results: The therapy was generally successful in reducing the levels of IL-6, IL-8, IL-10, and TNF-α but the levels measured after the procedure did not differ among the patients with or without sepsis, suggesting that the presence of sepsis did not affect the efficacy and function of the cytokine hemadsorption procedure in COVID-19 patients. All parameters were reduced after the procedure except the levels of PCT and ferritin and mortality rates of patients diagnosed with sepsis. The level of PCT was significantly higher in these patients compared with the patients without sepsis while the ferritin and mortality did not show any significant difference between the two groups, suggesting that the cytokine hemadsorption may be safe in the treatment of critical COVID-19 patients. Conclusions: As a result, the progression of sepsis in COVID-19 may be avoided with cytokine hemadsorption applied as an immunomodulator therapy. However, this therapy should be further explored and validated prior to its introduction to everyday clinical practice when the epidemic conditions end.
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    The natural course of non-alcoholic fatty liver disease.
    (2020-01-20) Seval G. C.; Kabacam G.; Yakut M.; Seven G.; Savas B.; Elhan A.; Cinar K.; Idilman R.; SEVEN, GÜLSEREN
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    Core Needle Biopsy in the Diagnosis of Thyroid Nodules
    (2022-11-01) Aysan E.; GÜLER B.; KIRAN T.; Idiz U. O.; GÜLER, BERIL; KIRAN, TUĞÇE
    Background Core needle biopsy (CNB) is a relatively new technique for the diagnosis of thyroid nodules, and there are currently no large clinical series available. CNB results from 3000 cases are presented in this article. Methods A spring-loaded 20-gauge needle was used for CNB under local anesthesia and ultrasonography guidance for 3000 patients with nodular goiter (584 males, 2416 females, mean age: 48.5). One physician performed all biopsy procedures without conducting on-site pathological examinations. Results There were non-diagnostic 22 (.7%), benign 2620 (87.4%), atypia of undetermined significance and/or, follicular lesion of undetermined significance 90 (3%), follicular neoplasms and/or suspicious for follicular neoplasm 53 (1.7%), suspicious for malignancy 160 (5.4%), and malignant 55 (1.8%) cases. The CNB procedure was repeated in 19 non-diagnostic cases, and 17 of these patients were benign and two had malignancy. Thyroidectomy was performed on patients who had malign CNB results. All final pathology reports, except for one, were malignant for the patients who had malignant CNB results. The specificity and the sensitivity of CNB were found to be 99.9% and 100%, respectively. There were no serious complications. Conclusion In thyroid nodules, core needle biopsy is a highly sensitive, specific, and reliable method that could be performed by a single physician. It does not require on-site pathological analysis and has a low incidence of complications and non-diagnostic rates.
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    Early prediction of the severe course, survival, and ICU requirements in acute pancreatitis by artificial intelligence
    (2023-01-01) İnce A. T.; Silahtaroğlu G.; Seven G.; Koçhan K.; Yıldız K.; Şentürk H.; İNCE, ALİ TÜZÜN; SEVEN, GÜLSEREN; KOÇHAN, KORAY; ŞENTÜRK, HAKAN
    AbstractObjectiveTo evaluate the success of artificial intelligence for early prediction of severe course, survival, and intensive care unit(ICU) requirement in patients with acute pancreatitis(AP).MethodsRetrospectively, 1334 patients were included the study. Severity is determined according to the Revised Atlanta Classification(RAC). The success of machine learning(ML) method was evaluated by 13 simple demographic, clinical, etiologic, and laboratory features obtained on ER admission. Additionally, it was evaluated whether Balthazar-computerized tomography severity index(CTSI) at 48-h contributed to success. The dataset was split into two parts, 90% for ML(of which 70% for learning and 30% for testing) and 10% for validation and 5-fold stratified sampling has been utilized. Variable Importance was used in the selection of features during training phase of machine. The Gradient Boost Algorithm trained the machine by KNIME analytics platform. SMOTE has been applied to increase the minority classes for training. The combined effects of the measured features were examined by multivariate logistic regression analysis and reciever operating curve curves of the prediction and confidence of the target variables were obtained.ResultsAccuracy values for the early estimation of Atlanta severity score, ICU requirement, and survival were found as 88.20%, 98.25%, and 92.77% respectively. When Balthazar-CTSI score is used, results were found as 91.02%, 92.25%, and 98% respectively.ConclusionsThe ML method we used successfully predicted the severe course, ICU requirement and survival, with promising accuracy values of over 88%. If 48-h Balthazar-CTSI is included in the calculation, the severity score and survival rates increase even more.
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    Inflammatory bowel disease does not alter the clinical features and the management of acute pancreatitis: A prospective, multicentre, exact-matched cohort analysis
    (2022-01-01T00:00:00Z) Dohos, Dóra; Farkas, Nelli; Váradi, Alex; Erőss, Bálint; Párniczky, Andrea; Szentesi, Andrea; Hegyi, Péter; Sarlós, Patrícia; Czakó, László; Boros, Eszter; Hussein, Tamás; Márta, Katalin; Borka, Katalin; Doros, Attila; Hosszúfalusi, Nóra; Zubek, László; Molnár, Zsolt; Váncsa, Szilárd; Nagy, Rita; Bunduc, Stefania; Földi, Mária; Faluhelyi, Nándor; Farkas, Orsolya; Vincze, Áron; Kui, Balázs; Izbéki, Ferenc; Hamvas, József; Papp, Mária; Varga, Márta; Török, Imola; Mickevicius, Artautas; Maldonado, Elena Ramirez; Sallinen, Ville; Ince, ALİ TÜZÜN; Galeev, Shamil; Poropat, Goran; Stimac, Davor; Litvin, Andrey; Ozola-Zalite, Imanta; Pukitis, Aldis; Zadorozhna, Kristina; Gyökeres, Tibor; İNCE, ALİ TÜZÜN
    © 2022 The AuthorsObjective and aims: Acute pancreatitis in inflammatory bowel disease occurs mainly as an extraintestinal manifestation or a side effect of medications. We aimed to investigate the prognostic factors and severity indicators of acute pancreatitis and the treatment of patients with both diseases. Design: We performed a matched case-control registry analysis of a multicentre, prospective, international acute pancreatitis registry. Patients with both diseases were matched to patients with acute pancreatitis only in a 1:3 ratio by age and gender. Subgroup analyses were also carried out based on disease type, activity, and treatment of inflammatory bowel disease. Results: No difference in prognostic factors (laboratory parameters, bedside index of severity in acute pancreatitis, imaging results) and outcomes of acute pancreatitis (length of hospitalization, severity, and local or systemic complications) were detected between groups. Significantly lower analgesic use was observed in the inflammatory bowel disease population. Antibiotic use during acute pancreatitis was significantly more common in the immunosuppressed group than in the non-immunosuppressed group (p = 0.017). However, none of the prognostic parameters or the severity indicators showed a significant difference between any subgroup of patients with inflammatory bowel disease. Conclusion: No significant differences in the prognosis and severity of acute pancreatitis could be detected between patients with both diseases and with pancreatitis only. The need for different acute pancreatitis management is not justified in the coexistence of inflammatory bowel disease, and antibiotic overuse should be avoided.
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    The effect of adenosine triphosphate on sunitinib-induced cardiac injury in rats
    In this study, we aimed to show the effect of adenosine 5 --triphosphate (ATP) on sunitinib-induced cardiac injury in rats. The rats (n = 30) were divided equally into three groups as sunitinib group (SG), sunitinib plus ATP group (SAG), and healthy group (HG); 2 mg/kg ATP was injected intraperitoneally (ip) to the SAG group. Same volume normal saline as solvent was administered ip to the other two groups. After 1 h, 25 mg/kg sunitinib was applied orally via catheter to stomach in the SAG and SG groups. This procedure was repeated once daily for 5 weeks. At the end of this period, all animals were sacrificed and their cardiac tissue was removed. Malondialdehyde (MDA), total glutathione (tGSH), tumor necrosis factor alpha (TNF-alpha), and nuclear factor kappa B (NF-kappa B) levels in rats- cardiac tissues and troponin I (Tp-I) levels in rats- blood samples were evaluated. Histopathological analysis was also performed in cardiac tissues of the animals. MDA, TNF-alpha, NF-kappa B, and Tp-I levels were higher in the SG group compared to the SAG and HG groups (p < 0.001). tGSH levels of the SG group were lower than the SAG and HG groups (p < 0.001). The structure and morphology of cardiac muscle fibers and blood vessels were normal in the control group. In the SG group, obvious cardiac muscle tissue damage with dilated myofibers, locally atrophic myofibers, and congested blood vessels were observed. In the SAG group, marked amelioration in these findings was observed. We showed this for the first time that ATP administration exerts a protective effect against cardiac effects of sunitinib.
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    Waning of SARS-CoV-2 Vaccine-Induced Immune Response over 6 Months in Peritoneal Dialysis Patients and the Role of a Booster Dose in Maintaining Seropositivity
    (2022-05-01T00:00:00Z) Murt, Ahmet; Dinc, HARİKA ÖYKÜ; Altiparmak, Mehmet Riza; Yalin, Serkan F.; Yadigar, Serap; Parmaksiz, Ergun; Kocazeybek, Bekir; Pekpak, Meltem; Ataman, Muveddet Rezzan; DİNÇ, HARİKA ÖYKÜ
    Introduction: Although lower than general population, newly developed SARS-CoV-2 vaccines generate immune responses in end-stage kidney disease patients. However, the persistence of immune responses in the long term is not known yet. This study aimed to evaluate humoral immune responses in peritoneal dialysis (PD) patients over 6 months and to analyze the effects of the booster dose. Methods: Humoral immune responses of PD patients were measured after initial SARS-CoV-2 vaccinations and after 6 months following initial vaccinations. Immune responses were compared between patients who received and did not receive booster doses. PD patients were compared with 41 hemodialysis (HD) patients and 61 healthy controls. Humoral immune responses were measured by a commercial test that detects antibodies toward the receptor-binding domain of the spike protein of SARS-CoV-2. Results: Twenty PD patients were evaluated over 6 months. The initial seropositivity rate was 90.9% with inactivated vaccine and 100% with mRNA vaccine. Seropositivity decreased to 44.4% after 6 months, and a booster dose helped in maintaining the 100% of seropositivity (p = 0.005). Magnitude of humoral response at the 6th month was also higher in patients who received the third dose (1,132.8 +/- 769.6 AU/mL vs. 400.0 +/- 294.6 AU/mL; p = 0.015). Among patients who did not receive the third dose, those who got mRNA vaccine could maintain higher seropositivity than others who got inactivated vaccine (75% vs. 40% for PD, 81.8% vs. 50% for HD). Seropositivity and antibody levels were similar for PD and HD patients after 6 months (p = 0.24 and 0.56) but lower than healthy controls (p = 0.0013). Conclusion: SARS-CoV-2 vaccine-induced antibody levels and seropositivity of PD patients significantly fall after 6 months. A booster dose after around 3 months following initial immunization might help in maintaining seropositivity.
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    The Effect of Metformin on Ethanol- and Indomethacin-Induced Gastric Ulcers in Rats.
    (2022-08-10T00:00:00Z) İpek, BETÜL ESRA; Yüksel, Meral; Cumbul, Alev; Ercan, Feriha; Cabadak, Hülya; Aydın, Banu; Alican, İnci; İPEK, BETÜL ESRA
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    Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice
    (2022-05-01T00:00:00Z) Kukula, Osman; Kirmizikan, SEDA; Tiryaki, Emre Soner; Cicekli, Mustafa Nusret; Gunaydin, Caner; KIRMIZIKAN, SEDA
    Background: Psoriasis is a common skin disorder related to inflammation and immune response. However, many treatment modalities are present in the clinics, and drug conformity halts chronic treatment. Therefore, novel treatment options are still needed. In this study, the possible protective effect of asiatic acid is one of the active compounds present in Centella Asiatica, was investigated in the imiquimod-induced psoriasis murine model. Methods:Imiquimod (62.5 mg) was administered dorsal skin of the mice for 6 days. Animals were co-treated with low-dose (25 mg/kg, p.o.) and high-dose (100 mg/kg, p.o.) asiatic acid. The dorsal skin of the animals was daily scored for erythema, thickness, and scaling. At the end of the treatments, serum levels of IL-17A and IL-23 were determined by ELISA. Additionally, the dorsal skins of animals were histopathologically evaluated. Results: Asiatic acid (high-dose) prevented imiquimod-induced skin lesions and protected dermal integrity in addition decreasing mast cell infiltration due to the imiquimod. Furthermore, asiatic acid (high-dose) suppressed the imiquimod-induced increase in serum levels of IL-17A and IL-23. Conclusion: These results indicate that asiatic acid showed an anti-psoriatic effect in the imiquimod-induced psoriasis model via mediating IL-17A and IL-23 pathways. Because wound healing properties of asiatic acid are described, further investigations should be carried out to understand deeper mechanisms and possible use in dermatological pathologies such as psoriasis.
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    Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases.
    (2022-05-12T00:00:00Z) Kiss, Szabolcs; Kiss, Szabolcs; Pintér, József; Molontay, Roland; Nagy, Marcell; Farkas, Nelli; Farkas, Nelli; Sipos, Zoltán; Sipos, Zoltán; Pecze, László; Pecze, László; Földi, Mária; Földi, Mária; Vincze, Áron; Vincze, Áron; Takács, Tamás; Takács, Tamás; Halász, Adrienn; Halász, Adrienn; Faluhelyi, Nándor; Faluhelyi, Nándor; Farkas, Orsolya; Farkas, Orsolya; Váncsa, Szilárd; Váncsa, Szilárd; Erőss, Bálint; Erőss, Bálint; Párniczky, Andrea; Párniczky, Andrea; Hegyi, Péter; Hegyi, Péter; Fehérvári, Péter; Fehérvári, Péter; Czakó, László; Czakó, László; Izbéki, Ferenc; Izbéki, Ferenc; Boros, Eszter; Boros, Eszter; Hamvas, József; Hamvas, József; Varga, Márta; Varga, Márta; Mickevicius, Artautas; Mickevicius, Artautas; Nagy, Rita; Nagy, Rita; Bunduc, Stefania; Bunduc, Stefania; Hegyi, Péter Jenő; Hegyi, Péter Jenő; Márta, Katalin; Márta, Katalin; Borka, Katalin; Borka, Katalin; Doros, Attila; Doros, Attila; Hosszúfalusi, Nóra; Hosszúfalusi, Nóra; Zubek, László; Zubek, László; Molnár, Zsolt; Molnár, Zsolt; Szentesi, Andrea; Szentesi, Andrea; Bajor, Judit; Gódi, Szilárd; Sarlós, Patrícia; Czimmer, József; Szabó, Imre; Pár, Gabriella; Illés, Anita; Hágendorn, Roland; Németh, Balázs Csaba; Kui, Balázs; Illés, Dóra; Gajdán, László; Dunás-Varga, Veronika; Fejes, Roland; Papp, Mária; Vitális, Zsuzsanna; Novák, János; Török, Imola; Macarie, Melania; Ramírez-Maldonado, Elena; Sallinen, Ville; Galeev, Shamil; Bod, Barnabás; Ince, ALİ TÜZÜN; Pécsi, Dániel; Varjú, Péter; Juhász, Márk Félix; Ocskay, Klementina; Mikó, Alexandra; Szakács, Zsolt; İNCE, ALİ TÜZÜN
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    Comprehensive geriatric assessment in older people: an umbrella review of health outcomes.
    (2022-05-01T00:00:00Z) Veronese, Nicola; Demurtas, Jacopo; Smith, Lee; Barbagallo, Mario; Maggi, Stefania; Cella, Alberto; Cella, Alberto; Vanacore, Nicola; Aprile, Pierangelo Lora; Ferrucci, Luigi; Pilotto, Alberto; Alberto, Pilotto; Maria Cristina, Polidori; Alves, Mariana; Alves, Mariana; Benzinger, Petra; Berg, Nicolas; Brach, Julie; Cardoso, Irwin; Chefi, Ben; Ciurea, Annette; Cornejo Lingan Ana, Maria; Cotobal Rodeles, Santiago; Cruz-Jentoft, Alfonso; Curiale, Vito; Custodero, Carlo; Custodero, Carlo; Danielova, Libuse; Davies, Franco; De Groot, Aafke; De Groot, Cathrine; De Lepeleire, Jan; De Vries, Benjamin; Decock, Anne-Marie; Denkinger, Michael; Dikmeer, Ayse; Dini, Simone; Durand, Amaury; Fatin, Ami; Fernandes, Marilia; Ferrara, Nicola; Francis, Bahaa; Fratiglioni, Laura; Freiberger, Ellen; Galvin, Rose; Garmendia, Blanca; Gillain, Sophie; Gomez Pavon, Javier; Goudzwaard, J A; Greco, Antonio; Gruner, Heidi; Gunther, Bernd; Happe, Lisa; Hermush, Vered; Huibregtse Bimmel, Jan-Kees; Indiano, Ilaria; Isaak, Julia; Jaramillo, Javier; Kerminen, Hanna; Laocha Aoife, Ni; Lau, Sandra; Lozano, Isabel; Madeira Sarmento Ana, Teresa; Mangoni, Arduino; Marques da Silva, Pedro; Mars, Patricia; Matejovska-Kubesova, Hana; Mattace Raso, Francesco; Moeskops, Simone; Molnar, Andrea; Musacchio, Clarissa; Nagaratnam, Kiruba; Nieminen, Uomo; O'Connor, Margaret; Özge Kayhan Koçak, Fatma; Paccalin, Marc; Palikhe, Anil; Pavic, Tajana; Per Nordnes, Raymond; Platon, Izabela; Polinder, Harmke; Prada, Gabriel; Ragnheim, Ragnhild; Ramsawak, Lisa; Rewiuk, Krzysztof; Rodrigues, Carlos; Roller-Wirnsberger, Regina; Rossinen, Juhani; Ruotolo, Giovanni; Ruppe, Georg; Ryan, Dan; Sabba, Carlo; Sanchez, Elisabet; Savas, Sumru; Schmid, Veronika; Schroderus, Kaisa; Siegrist, Monica; Smedberg, Daniel; Smit, Orla; Soulis, George; Tampaki, Maria; Tenkattelaar, Natasia; Thiem, Ulrich; Topinkova, Eva; Tromp, Jorien; Van Beek, Michiel; Van Heijningen, Lars; Vandeelen, Bob; Vanderhulst, Heleen; Vankova, Hana; Verissimo, Rafaela; Vonk, Merel; Vrabie, Calin; Wearing, Paul; Weiss, Michael; Welmer, Anna-Karin; Werle, Berenice; Ylmaz, Ozlem; Shoaib Muhammad, Zaidi; Zamfir, Mihaela; Zanom, Ilo; Zuidhof, Jen; Nicola, Veronese; Lee, Smith; Avcy, Suna; Bahat-Ozturk, Gulistan; Balci, Cafer; Beaudart, Charlotte; Bruyère, Olivier; Cherubini, Antonio; Da Cruz Alves, Mariana; Firth, Joseph; Goisser, Sabine; Hursitoglu, Mehmet; Hurst, Christopher; Kemmler, Wolfgang; Kiesswetter, Eva; Kotsani, Marina; Koyanagi, Ai; Locquet, Médéa; Marengoni, Alessandra; Nida, Mahwish; Obretin Florian, Alexandru; O'Hanlon, Shane; Okpe, Andrew; Pedone, Claudio; Petrovic, Mirko; Pizzol, Damiano; Prokopidis, Konstantinos; Rempe, Hanna; Sanchez Rodrigues, Dolores; Schoene, Daniel; Schwingshackl, Lukas; Shenkin, Susan; Solmi, Marco; Soysal, PINAR; Stubbs, Brendon; Thompson, Trevor; Torbahn, Gabriel; Unim, Brigid; SOYSAL, PINAR
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    The course of acute pancreatitis in patients with different BMI groups.
    (2022-03-17T00:00:00Z) İnce, Ali Tüzün; Seven, Gülseren; Koçhan, Koray; Kiremitçi, Sercan; Yıldız, Kemal; Şentürk, Hakan; İNCE, ALİ TÜZÜN
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    Effects of severe hydronephrosis on the outcomes of percutaneous nephrolithotomy with one-shot dilation method
    (2021-03-01T00:00:00Z) Micoogullari, Uygar; Yucel, Cem; Sueluzgen, Tufan; Kisa, Erdem; Keskin, Mehmet Zeynel; Isoglu, Cemal Selcuk; Ilbey, YUSUF ÖZLEM; İLBEY, YUSUF ÖZLEM
    Objective: To investigate the effect of the presence of severe hydronephrosis on percutaneous nephrolithotomy (PNL) outcome in patients who underwent PNL operation with one-shot dilatation technique.
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    Predictive effect of preoperative anemia on long-term survival outcomes with non-muscle invasive bladder cancer
    (2016-01-01T00:00:00Z) Celik, Orcun; Akand, Murat; Keskin, Mehmet Zeynel; Ekin, Rahmi Gokhan; Yoldas, Mehmet; Ilbey, YUSUF ÖZLEM; İLBEY, YUSUF ÖZLEM
    Background: Anemia is the most common hematologic abnormality in bladder cancer (BC) patients. We evaluated the impact of preoperative anemia on oncologic outcomes in BC undergoing transurethral resection of a bladder tumor (TURBT) for the first time diagnosis. Materials and Methods: We retrospectively evaluated the data collected from 639 patients who underwent TURBT between January 2006 and September 2014 in our department. Of these patients, 320 qualified for inclusion in the study. The primary efficacy endpoint was the effect of preoperative anemia status on cancer-specific and overall survival. Independent t-test and chi-square analyses were performed to assess the effects of anemia on oncologic outcomes. Survival was estimated by using the Kaplan-Meier test. Results: There were 118 (36.9%) and 202 (63.1%) patients in the anemia (Group-1) and non-anemia groups (Group-2), respectively. The median follow-up duration was 68 months. Anemia was associated with decreased overall survival (p < 0.001). Comparison between cancer-specific survival of two groups did not show any statistically significant difference (p=0.17). Conclusions: Preoperative anemia status of BC patients according to World Health Organization classification is associated with decreased overall survival, but not with cancer-specific survival. We think that preoperative hemoglobin levels should be considered in patient counseling and decision-making for additional therapy.
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    Our percutaneous nephrolitotomy experience in patients with horseshoe kidney
    (2015-01-01T00:00:00Z) Suelozgen, Tufan; Isoglu, Cemal Selcuk; Turk, Hakan; Yoldas, Mehmet; Ilbey, Ozlem Yusuf; Zorlu, Ferruh; İLBEY, YUSUF ÖZLEM
    Objectives: Horseshoe kidney is the most common renal congenital fusion anomaly. Kidney stone formation is more common in horseshoe kidneys and some of them requires surgical procedure. So we want to evaluate the results of PNL in patients with horseshoe kidney anomaly.
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    Magnetic resonance imaging characteristics and changes in hemostatic agents after partial nephrectomy
    (2019-06-01T00:00:00Z) Kisa, Erdem; Sahin, Hilal; Cakmak, Ozgur; Yucel, Cem; Koc, Gokhan; Kozacioglu, Zafer; Ilbey, YUSUF ÖZLEM; İLBEY, YUSUF ÖZLEM
    Purpose To evaluate the characteristics of images generated by magnetic resonance imaging (MRI) and changes in the mass-like lesion (MLL) during the follow-up of patients who underwent partial nephrectomy (PN) with the intra-operative use of hemostatic agents (HAs).
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    Can We Use Single-step Dilation as a Safe Alternative Dilation Method in Percutaneous Nephrolithotomy?
    (2017-01-01T00:00:00Z) Suelozgen, Tufan; Isoglu, Cemal Selcuk; Turk, Hakan; Yoldas, Mehmet; Karabicak, Mustafa; Ergani, Batuhan; Boyacioglu, Hayal; Ilbey, YUSUF ÖZLEM; İLBEY, YUSUF ÖZLEM
    OBJECTIVE To examine the outcomes of the patients who underwent percutaneous nephrolithotomy with single-step dilatation technique in our clinic.