Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII

Göster/ Aç
Tarih
2019-05-01Yazar
BUA, SilviaAkdemir, ATİLLA
Guzel-Akdemir, Ozlen
Supuran, Claudiu T.
Demir-Yazici, Kubra
Akgunes, Nurgul Mutlu
Danışman
Türü
Üst veri
Tüm öğe kaydını gösterÖzet
Novel sulfonamidoindole-based hydrazones with a 2-(hydrazinocarbonyl)-3-phenyl-1Hindole-5-sulfonamide scaffold were synthesized and tested in enzyme inhibition assays against the
tumor-associated carbonic anhydrase isoforms, hCA IX and XII, and the off-targets, hCA I and II.
The compounds showed selectivity against hCA IX and XII over hCA I and II. Six compounds showed
KI values lower than 10 nM against hCA IX or XII. Molecular modeling studies were performed to
suggest binding interactions between the ligand and the hCA active sites.
Koleksiyonlar
- Eczacılık Fakültesi [429]
- PubMed İndeksli Yayın Koleksiyonu [3700]
- Scopus İndeksli Yayınlar Koleksiyonu [4458]
- WoS İndeksli Yayınlar Koleksiyonu [5221]
- Yayınlar - Eserler [10056]