Publication:
Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII

Simple item page
dc.contributor.authorDemir-Yazici, Kubra
dc.contributor.authorBUA, Silvia
dc.contributor.authorAkgunes, Nurgul Mutlu
dc.contributor.authorAkdemir, ATİLLA
dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorGuzel-Akdemir, Ozlen
dc.contributor.institutionauthorAKDEMİR, ATİLLA
dc.date.accessioned2019-10-05T14:17:08Z
dc.date.available2019-10-05T14:17:08Z
dc.date.issued2019-05-01
dc.description.abstractNovel sulfonamidoindole-based hydrazones with a 2-(hydrazinocarbonyl)-3-phenyl-1Hindole-5-sulfonamide scaffold were synthesized and tested in enzyme inhibition assays against the tumor-associated carbonic anhydrase isoforms, hCA IX and XII, and the off-targets, hCA I and II. The compounds showed selectivity against hCA IX and XII over hCA I and II. Six compounds showed KI values lower than 10 nM against hCA IX or XII. Molecular modeling studies were performed to suggest binding interactions between the ligand and the hCA active sites.en
dc.description.sponsorshipİstanbul Üniversitesi
dc.identifier10.5505/yeditepe.2018.25743
dc.identifier.citationDemir-Yazici K., BUA S., Akgunes N. M. , Akdemir A., Supuran C. T. , Guzel-Akdemir O., -Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII-, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.20, 2019
dc.identifier.doi10.3390/ijms20092354
dc.identifier.pubmed31083645
dc.identifier.scopus85066061593
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3452
dc.identifier.wosWOS:000469753500301
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleIndole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameYeditepe Dental Journal
local.avesis.id53d41336-d38e-4e23-b8ca-67248185d926
local.avesis.response3322
local.publication.isinternational1
relation.isAuthorOfPublication19bc513a-c695-4e72-ba1d-83b8d6c574c8
relation.isAuthorOfPublication.latestForDiscovery19bc513a-c695-4e72-ba1d-83b8d6c574c8
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
104-10.3390-ijms20092354.pdf
Size:
1.67 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler
Eczacılık Fakültesi