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Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma

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ijms-22-01318-v2.pdf (1.272Mb)
Date
2021-02-01
Author
KHAN, IMRAN
Baig, Mohammad Hassan
Mahfooz, Sadaf
Rahim, Moniba
KARAÇAM, BÜŞRA
ELBASAN, Elif Burçe
Ulasov, Ilya
Dong, Jae-June
HATİBOĞLU, MUSTAFA AZİZ
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Article
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Abstract
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Autophagy is a process essential for cellular energy consumption, survival, and defense mechanisms. The role of autophagy in several types of human cancers has been explicitly explained; however, the underlying molecular mechanism of autophagy in glioblastoma remains ambiguous. Autophagy is thought to be a -double-edged sword-, and its effect on tumorigenesis varies with cell type. On the other hand, autophagy may play a significant role in the resistance mechanisms against various therapies. Therefore, it is of the utmost importance to gain insight into the molecular mechanisms deriving the autophagy-mediated therapeutic resistance and designing improved treatment strategies for glioblastoma. In this review, we discuss autophagy mechanisms, specifically its pro-survival and growth-suppressing mechanisms in glioblastomas. In addition, we try to shed some light on the autophagy-mediated activation of the cellular mechanisms supporting radioresistance and chemoresistance in glioblastoma. This review also highlights autophagy’s involvement in glioma stem cell behavior, underlining its role as a potential molecular target for therapeutic interventions.
Subject
autophagy
URI
http://hdl.handle.net/20.500.12645/28410
https://www.mdpi.com/1422-0067/22/3/1318
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS