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Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma

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dc.contributor.authorKHAN, IMRAN
dc.contributor.authorBaig, Mohammad Hassan
dc.contributor.authorMahfooz, Sadaf
dc.contributor.authorRahim, Moniba
dc.contributor.authorKARAÇAM, BÜŞRA
dc.contributor.authorELBASAN, Elif Burçe
dc.contributor.authorUlasov, Ilya
dc.contributor.authorDong, Jae-June
dc.contributor.authorHATİBOĞLU, MUSTAFA AZİZ
dc.contributor.institutionauthorKHAN, IMRAN
dc.contributor.institutionauthorKARAÇAM, BÜŞRA
dc.contributor.institutionauthorELBASAN, ELİF BURÇE
dc.contributor.institutionauthorHATİBOĞLU, MUSTAFA AZİZ
dc.date.accessioned2021-02-11T20:59:05Z
dc.date.available2021-02-11T20:59:05Z
dc.date.issued2021-02-01T00:00:00Z
dc.description.abstractAutophagy is a process essential for cellular energy consumption, survival, and defense mechanisms. The role of autophagy in several types of human cancers has been explicitly explained; however, the underlying molecular mechanism of autophagy in glioblastoma remains ambiguous. Autophagy is thought to be a -double-edged sword-, and its effect on tumorigenesis varies with cell type. On the other hand, autophagy may play a significant role in the resistance mechanisms against various therapies. Therefore, it is of the utmost importance to gain insight into the molecular mechanisms deriving the autophagy-mediated therapeutic resistance and designing improved treatment strategies for glioblastoma. In this review, we discuss autophagy mechanisms, specifically its pro-survival and growth-suppressing mechanisms in glioblastomas. In addition, we try to shed some light on the autophagy-mediated activation of the cellular mechanisms supporting radioresistance and chemoresistance in glioblastoma. This review also highlights autophagy’s involvement in glioma stem cell behavior, underlining its role as a potential molecular target for therapeutic interventions.
dc.identifier.citationKHAN I., Baig M. H. , Mahfooz S., Rahim M., KARAÇAM B., ELBASAN E. B. , Ulasov I., Dong J., HATİBOĞLU M. A. , -Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma-, International Journal of Molecular Sciences, cilt.22, ss.1-26, 2021
dc.identifier.doi10.3390/ijms22031318
dc.identifier.pubmed33525678
dc.identifier.scopus85099956086
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28410
dc.identifier.urihttps://www.mdpi.com/1422-0067/22/3/1318
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectautophagy
dc.subjectchemoresistance
dc.subjectglioblastoma
dc.subjectglioma stem cells
dc.subjectmolecular targets
dc.subjectradioresistance
dc.titleDeciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma
dc.typeArticle
dspace.entity.typePublication
local.avesis.id3d2fbad5-0c06-4fb0-917b-02d277e9fc91
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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