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Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies.

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Date
2020-06-19T00:00:00Z
Authors
Soysal, PINAR
Hurst, C
Demurtas, J
Firth, J
Howden, R
Yang, L
Tully, MA
Koyanagi, A
Ilie, PC
López-Sánchez, GF
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Research Projects
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Abstract
Purpose: The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes. Methods: An umbrella review of systematic reviews with meta-analyses of observational studies was conducted. We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values, 95% prediction intervals, heterogeneity, small-study effects, and excess significance. We graded the evidence from convincing (Class I) to weak (Class IV). Results: From 504 articles returned in a search of the literature, 8 systematic reviews were included in our review, with a total of 11 outcomes. Overall, 9 of the 11 of the outcomes reported nominally significant summary results (p < 0.05), with 4 associations surviving the application of the more stringent p value (p < 10-6). No outcome presented convincing evidence. Three associations showed Class II evidence (i.e., highly suggestive): (1) higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population (n = 34 studies; sample size = 1,855,817; relative risk = 0.72; 95% confidence interval (CI): 0.67-0.78), (2) cardiovascular death risk in mixed populations (n = 15 studies; relative risk = 0.84; 95%CI: 0.78-0.91), and (3) incidence of disability (n = 7 studies; relative risk = 0.76; 95%CI: 0.66-0.87). Conclusion: The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality, as well as disability. To further inform intervention strategies, future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.
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Handgrip strength, Meta-analysis
Citation
Soysal P., Hurst C., Demurtas J., Firth J., Howden R., Yang L., Tully M., Koyanagi A., Ilie P., López-Sánchez G., et al., -Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies.-, Journal of sport and health science, 2020
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