Publication: Synthesis, Complexation, and Biological Activity Studies of 4-Aminomethyl-7,8-dihydroxy Coumarines and Their Crown Ether Derivatives
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Date
2010-09-01T00:00:00Z
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Gumus, Arzu
Karadeniz, Seref
Ugras, Halil Ibrahim
Bulut, Mustafa
Cakir, Umit
Goren, AHMET CEYHAN
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Abstract
The article focuses synthesis of novel 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca(2+), Mg(2+), Fe(2+), Zn(2+), Ni(2+), Cd(2+), Co(2+), and Mn(2+) ions at 25 degrees C +/- 0.1 with the 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma-Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity.
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Gumus A., Karadeniz S., Ugras H. I. , Bulut M., Cakir U., Goren A. C. , -Synthesis, Complexation, and Biological Activity Studies of 4-Aminomethyl-7,8-dihydroxy Coumarines and Their Crown Ether Derivatives-, JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.47, ss.1127-1133, 2010