Publication: Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
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Date
2013-01-01T00:00:00Z
Authors
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Kilic, Ulkan
KILIÇ, ERTUĞRUL
TUZCU, ZEYNEP
TUZCU, MEHMET
ÖZERCAN, İBRAHİM HANİFİ
YILMAZ, ÖKKEŞ
ŞAHİN, FİKRETTİN
ŞAHİN, KAZİM
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Abstract
Background: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effects such as nephrotoxicity and ototoxicity. Cisplatin chemotherapy induces a reduction in the antioxidant status, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drugs. Cisplatin-induced oxidative stress in the kidney was partially prevented by antioxidant treatments using superoxide dismutase, glutathione, selenium and flavonoids. Melatonin and its metabolites possess free-radical scavenging activity and it has been shown that they protect against cisplatin toxicity. However, the mechanism of the protective effects of melatonin against cisplatin-induced nephrotoxicity is still essentially unknown. We therefore designed this study to investigate the underlying mechanism of the protective effect of melatonin against cisplatin-induced renal damage in a rat nephrotoxicity model in vivo.
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Nephrotoxicity
Citation
Kilic U., KILIÇ E., TUZCU Z., TUZCU M., ÖZERCAN İ. H. , YILMAZ Ö., ŞAHİN F., ŞAHİN K., -Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway-, NUTRITION & METABOLISM, cilt.10, 2013