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Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

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dc.contributor.authorKilic, Ulkan
dc.contributor.authorKILIÇ, ERTUĞRUL
dc.contributor.authorTUZCU, ZEYNEP
dc.contributor.authorTUZCU, MEHMET
dc.contributor.authorÖZERCAN, İBRAHİM HANİFİ
dc.contributor.authorYILMAZ, ÖKKEŞ
dc.contributor.authorŞAHİN, FİKRETTİN
dc.contributor.authorŞAHİN, KAZİM
dc.date.accessioned2020-10-22T20:23:05Z
dc.date.available2020-10-22T20:23:05Z
dc.date.issued2013-01-01T00:00:00Z
dc.description.abstractBackground: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effects such as nephrotoxicity and ototoxicity. Cisplatin chemotherapy induces a reduction in the antioxidant status, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drugs. Cisplatin-induced oxidative stress in the kidney was partially prevented by antioxidant treatments using superoxide dismutase, glutathione, selenium and flavonoids. Melatonin and its metabolites possess free-radical scavenging activity and it has been shown that they protect against cisplatin toxicity. However, the mechanism of the protective effects of melatonin against cisplatin-induced nephrotoxicity is still essentially unknown. We therefore designed this study to investigate the underlying mechanism of the protective effect of melatonin against cisplatin-induced renal damage in a rat nephrotoxicity model in vivo.
dc.identifier.citationKilic U., KILIÇ E., TUZCU Z., TUZCU M., ÖZERCAN İ. H. , YILMAZ Ö., ŞAHİN F., ŞAHİN K., -Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway-, NUTRITION & METABOLISM, cilt.10, 2013
dc.identifier.doi10.1186/1743-7075-10-7
dc.identifier.pubmed23311701
dc.identifier.scopus84872136337
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24744
dc.identifier.urihttps://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-10-7
dc.identifier.wosWOS:000314541600001
dc.subjectNephrotoxicity
dc.titleMelatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide26a7032-9ed6-415f-90c9-18608fbd7c94
local.publication.isinternational1
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