Publication: IL-6 mediated JAK/STAT3 signaling pathway in cancer patients with cachexia
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2019-01-01T00:00:00Z
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Eskiler, Guney G.
Bezdegumeli, E.
Ozman, Zeynep
Ozkan, Deveci A.
Bilir, C.
Kucukakca, B. N.
Ince, M. N.
Men, A. Y.
Aktas, O.
Horoz, Y. E.
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Abstract
OBJECTIVES: We investigated the changes in the IL-6 and STAT3 expression levels in cachectic and non-cachectic patients with gastric, lung and breast cancer and evaluated the association between IL-6 and STAT3 levels and cancer types in terms of cachexia condition. BACKGROUND: Cancer-associated cachexia, observed in nearly 50.80 % of cancer patients, has drawn attention in advanced patients. IL-6/JAK/STAT pathway plays an essential role in the progression of cancer cachexia through the regulation of the inflammatory response.
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Eskiler G. G. , Bezdegumeli E., Ozman Z., Ozkan D. A. , Bilir C., Kucukakca B. N. , Ince M. N. , Men A. Y. , Aktas O., Horoz Y. E. , et al., -IL-6 mediated JAK/STAT3 signaling pathway in cancer patients with cachexia-, BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.120, ss.819-826, 2019