Publication: Short Term Effect of Percutaneous Recanalization of Chronic Total Occlusions on QT Dispersion and Heart Rate Variability Parameters
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Date
2013-10-01T00:00:00Z
Authors
Authors
Erdogan, Ercan
Akkaya, Mehmet
BACAKSIZ, AHMET
Tasal, Abdurrahman
Kul, Seref
Turfan, Murat
Sonmez, Osman
Vatankulu, Mehmet Akif
Asoglu, Emin
Sevgili, Emrah
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Abstract
Background: QT dispersion (QTd), which is a measure of inhomogeneity of myocardial repolarization, increases following impaired myocardial perfusion. Its prolongation may provide a suitable substrate for life-threatening ventricular
arrhythmias. We investigated the changes in QTd and heart rate variability (HRV) parameters after successful
coronary artery revascularization in a patient with chronic total occlusions (CTO).
Material/Methods: This study included 139 successfully revascularized CTO patients (118 men, 21 women, mean age 58.3±9.6
years). QTd was measured from a 12-lead electrocardiogram and was defined as the difference between maximum and minimum QT interval. HRV analyses of all subjects were obtained. Frequency domain (LF: HF) and
time domain (SDNN, pNN50, and rMSSD) parameters were analyzed. QT intervals were also corrected for heart
rate using Bazett’s formula, and the corrected QT interval dispersion (QTcd) was then calculated. All measurements were made before and after percutaneous coronary intervention (PCI).
Results: Both QTd and QTcd showed significant improvement following successful revascularization of CTO (55.83±14.79
to 38.87±11.69; p<0.001 and 61.02±16.28 to 42.92±13.41; p<0.001). The revascularization of LAD (n=38), Cx
(n=28) and RCA (n=73) resulted in decrease in HRV indices, including SDDN, rMSSD, and pNN50, but none of
the variables reached statistical significance.
Conclusions: Successful revascularization of CTO may result in improvement in regional heterogeneity of myocardial repolarization, evidenced as decreased QTcd after the PCI. The revascularization in CTO lesions does not seem to
have a significant impact on HRV
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Keywords
Percutaneous Recanalization
Citation
Erdogan E., Akkaya M., BACAKSIZ A., Tasal A., Kul S., Turfan M., Sonmez O., Vatankulu M. A. , Asoglu E., Sevgili E., et al., -Short Term Effect of Percutaneous Recanalization of Chronic Total Occlusions on QT Dispersion and Heart Rate Variability Parameters-, 29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation, Antalya, Türkiye, 26 - 29 Ekim 2013, cilt.62