Person: BACAKSIZ, AHMET
63 results
Search Results
Now showing 1 - 10 of 63
Publication The effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease(2015-02-01) IZMIRLI, Muzeyyen; GOKTEKIN, Omer; Bacaksiz, AHMET; Uysal, Omer; Kilic, Ulkan; BACAKSIZ, AHMET; UYSAL, ÖMERObjective: Cardiovascular disease (CVD) is the leading cause of death in Europe. One of the candidate molecule affecting epigenetic mechanisms of CVD is the SIRT1, a subclass of sirtuins, is located on the long arm of chromosome 10 (10q21.3). Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. One of the activator of SIRT1, resveratrol, is also known as a cardioprotective molecule. On the other hand, the parameters including exercise, occupation and age affect CVD. The aim of the present study was to investigate the effect of the rs144124002 (2827 A>G) single nucleotide polymorphisms (SNP) of SIRT1 and exercise-occupation-age parameters on CVD. Methods: SNP of SIRT1 were analyzed using DNA isolation, the polymerase chain reaction (PCR) and restriction fragment length polymorphism. To do so, large cohorts of CVD patients (n=293) and healthy controls (n=117) who directed Cardiology Department of Bezmialem Vakıf University, Bezmialem Vakıf University Hospital were used. Results: In this study, when we assessed CVD and control groups about 2827 A>G polymorphism, all individuals were determined as homozygous genotype. We found a positive effect between the modifications of resveratrol, exercise, age and occupation and CVD (OR=0.17; CI 95%, 0.1-0.2; p≤0.001). Conclusion: This is the first study demonstrating the correlation between the SIRT1 rs144124002 polymorphism and CVD in Turkish population. (Anatolian J Cardiol 2015; 15: 103-6) Key words: SIRT1, resveratrol, epigenetic, polymorphism, cardiovascular diseasePublication Heart sound recognition with deep neural networks(2018-10-24) MUTLUER, ahmet serdar; AKMAN, Alican; BACAKSIZ, AHMET; ÖZDEMİR, RAMAZAN; Enhoş, ASİM; AYDIN, TEOMAN; KESKİN, YAŞAR; UÇAR, Oğuzhan; BACAKSIZ, AHMET; ÖZDEMİR, RAMAZAN; ENHOŞ, ASIM; AYDIN, TEOMAN; KESKİN, YAŞARPublication Bulky calcification on the left coronary cuspis causing to critical stenosis of LMCA ostium after a succesful TAVI procedure(2017-10-08T00:00:00Z) BAKSHALİYEV, NİJAD; NASİFOV, MAHARRAM; ENHOŞ, ASİM; ÖZDEN TOK, ÖZGE; KARAÇÖP, ERDEM; ULUGANYAN, MAHMUT; HUYUT, MUSTAFA AHMET; BACAKSIZ, AHMET; ÇELİKKALE, İLKE; AKDEMİR, BARIŞ; GÖKTEKİN, ÖMER; ENHOŞ, ASIM; KARAÇÖP, ERDEM; ULUGANYAN, MAHMUT; BACAKSIZ, AHMET; ÇELİKKALE, İLKEPublication High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction(2012-12-01T00:00:00Z) Kul, Seref; Akgul, Ozgur; Uyarel, Huseyin; Ergelen, Mehmet; Kucukdagli, Okkes T.; Tasal, Abdurrahman; Erdogan, Ercan; BACAKSIZ, AHMET; Sonmez, Osman; Gul, Mehmet; Uslu, Nevzat; Goktekin, Omer; BACAKSIZ, AHMETObjective A high SYNTAX score (SXscore) is a predictor of adverse outcomes for stable and unstable coronary syndromes. We aimed to examine whether a high SXscore will determine in-hospital clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.Publication Dirençli Hipertansiyonlu Hastalarda H. Pylori Sıklığı Ve H. Pylori Eradikasyonun Yüksek Kan Basıncı Üzerine Etkisi.(2017-10-14T00:00:00Z) Karatoprak, Cumali; Hamdard, Jamshid; Bacaksız, Ahmet; KARATOPRAK, CUMALİ; BACAKSIZ, AHMETAims: Helicbacter pylorinin (H. pylori) ekstraintestinal olarak birçok patolojiye neden olduğu bilinmektedir. H. pylori eradikasyonunun primer hipertansiyon üzerinde pozitif etkileri olduğunu gösteren çalışmalar mevcuttur. Bu çalışmada biri diüretik olmak üzere 3 antihipertansif ilaç kullanımına rağmen sistolik kan basıncının >140 mm-Hg ve diyastolik kan basıncının >90 mm-Hg olan dirençli hipertansif hastalarda H. pylori sıklığı ve eradikasyonun kan basıncı kontrolü üzerine etkisi araştırılmıştır.Materials and Methods: Bu çalışma prospektif gözlemsel bir çalışmadır. Hastalardan gaitada H.pylori antijeni bakılan ve dirençli hipertansiyonu olan hastalar toplandı. Bütün hastaların ambulatuvar kan basınç monitörizasyonu ile 24 saatlik kan basınçları ölçüldü ve ortalama kan basıncı sistolik 140 mmhg ve/veya diastolik 90 mm-Hg’nın üzerinde olan hastalar çalışmaya alındı. Çalışmaya uygun bulunan hastalar H.pylori pozitif olanlar bir grup negatif olanlar diğer grup olmak üzere ikiye ayrıldı. H. pylori antijeni negatif olan hastalarda tedaviye uyum, tuzsuz beslenme ve kilo vermenin önemi anlatılarak 6 hafta sonra kontrole çağrıldı ve 24 saatlik kan basıncı monitorizasyonu tekrar yapıldı. H. pylori antijeni pozitif olan hastalara 14 günlük standart (lansoprozol, amoksisilin ve klaritromisin) H. pylori eradikasyon tedavisi verildi. Eradikasyon tedavisi bittikten 4 hafta sonraki kontrollerinde dışkıda H. pylori antijeni negatif olanlarda eradikasyon başarılı kabul edildi. Dirençli esansiyel hipertansiyonlu hastalarda 6 haftalık aralarla elde edilen sistolik ve diyastolik kan basınçları karşılaştırıldı.Results: Çalışmaya 12 H. pylori (+) 37 H. pylori (-) olmak üzere toplam 49 hasta katılmıştır.Bu çalışmada H. pylori sıklığı %24.5 bulunmuştur. H.pylori (+) hastalar tedavi edildiğinde hem sistolik (26.7 mm-Hg) hemde diastolik (9 mm-Hg) kan basıncında anlamlı düşüşler gözlenmiştir (P=0.002, P=0.011 respectively). Diğer taraftan H.pylori (-) olanlarda tedavi uyumunun arttırılmasına yönelik önerilere rağmen hem sistolik (-0.5 mm-Hg) hem de diastolik (0.3 mm-Hg) kan basıncında anlamlı bir değişiklik olmamıştır (P=0.52, P=0.73, sırasıyla). Conclusion: Bu sonuçlar direçli hipertansiyonu olan hastalarda H. pylori aranması gerektiğini düşündürmektedir. Ve eğer H. pylori pozitif saptanırsa eradikasyon tedavisinin arterial kan basıncı kontrolunu sağlamada yardımcı olabileceğini düşündürmektedir.Publication SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases(2014-02-28) KILIC, Ulkan; GOK, Ozlem; Bacaksiz, AHMET; IZMIRLI, Muzeyyen; Elibol-Can, BİRSEN; Uysal, Omer; BACAKSIZ, AHMET; ELİBOL, BİRSEN; UYSAL, ÖMERCardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs) (rs7895833 A.G in the promoter region, rs7069102 C.G in intron 4 and rs2273773 C.T in exon 5 silent mutation) and SIRT1 and eNOS (endothelial nitric oxide synthase) protein expression as well as total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in CVD patients as compared to controls. The frequencies of mutant genotypes and alleles for rs7069102 and rs2273773 were significantly higher in patients with CVD compared to control group. The risk for CVD was increased by 2.4 times for rs7069102 and 1.9 times for rs2273773 in carriers of mutant allele compared with carriers of wild-type allele pointing the protective role of C allele for both SNPs against CVD. For rs7895833, there was no significant difference in genotype and allele distributions between groups. SIRT1 protein, TAS, TOS and OSI levels significantly increased in patients as compared to control group. In contrast, level of eNOS protein was considerably low in the CVD patients. An increase in the SIRT1 expression in the CVD patients carrying mutant genotype for rs7069102 and heterozygote genotype for all three SNPs was observed. This is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSIPublication Endovascular Therapy of Acute Ischemic Stroke by Interventional Cardiologists: National Initial Experience(2013-10-29) TASAL, Abdurrahman; Bacaksiz, AHMET; VATANKULU, Mehmet Akif; SONMEZ, Osman; TURFAN, Murat; ERDOGAN, Ercan; KARADELI, Hasan Huseyin; Kolukisa, MEHMET; KUL, Seref; ALTINTAS, Ozge; Asil, TALİP; GOKTEKIN, Omer; BACAKSIZ, AHMET; KOLUKISA, MEHMET; ASİL, TALIPObjectives: We report our initial experience with thrombectomy devices in patients with acute ischemic stroke. Study design: Demographic, clinical, and angiographic findings of 19 consecutive patients (7 females and 12 males; mean age 61.4±12.5 years) with acute ischemic stroke were evaluated retrospectively. Results: The mean initial National Institutes of Health Stroke Scale (NIHSS) score was 19.5±5.6. Middle cerebral artery was the occluded artery in all of the patients (proximal occlusion in 11, distal in 8 and tandem occlusions in 7 patients). Successful revascularization was achieved in 16 patients (84%). The mean NIHSS score was 8.4±8.2 at 24 hours after the procedure, and 60% of patients showed a modified Rankin scale score of ≤2 at 90 days. New occlusion by migrated emboli was observed in 2 (11%) cases. None of the patients had experienced post-procedural symptomatic intracerebral hemorrhage; 3 patients died during the three-month follow-up. In all patients, thrombectomy was performed with retrievable Solitaire AB stent system. Conclusion: This single-center experience with mechanical thrombectomy devices demonstrated that high success rates can be achieved by experienced interventional cardiologists in equipped cath labs throughout the country.Publication Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study(2013-12-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Turfan, Murat; Kul, Seref; Sonmez, Osman; Vatankulu, Mehmet Akif; Ertas, Gokhan; Batmaz, Gonca; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETObjective: Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Methods: Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function as well as two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global longitudinal strain (GLS) was calculated from 3 standard apical views using 2D-STE. Student t-test, Chi-square test, Pearson's, and Spearman's correlation analysis were used for statistical analysis. Results: The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio were increased in the PCOS group (p<0.05 for all). Waist-to-hip ratio, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and low-density lipoprotein (LDL) levels were higher in PCOS group (p<0.05 for all). Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR (p<0.05 for all). On 3D-Echo evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LV ejection fraction and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78 +/- 0.56% vs. -18.36 +/- 1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values (p<0.05 for all). Conclusion: These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population.Publication Comparison of single-dose and repeated levosimendan infusion in patients with acute exacerbation of advanced heart failure(2014-02-01T00:00:00Z) Tasal, Abdurrahman; DEMİR, MESUT; KANADAŞI, MEHMET; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Sahin, Durmus Yildiray; Eker, Rabia Akilli; BOZKURT, ABDİ; Acarturk, Esmeray; BACAKSIZ, AHMETBackground: Levosimendan (LS) is a novel inodilator that improves cardiac performance, central hemodynamics, and symptoms of patients with decompensated chronic heart failure. The aim of this study was to compare the effects of single and repeated LS infusion on left ventricular performance, biomarkers, and neurohormonal activation in patients with acute heart failure.Publication Valve sparing surgery in an adult patient with dextrocardia and annuloaortic ectasia(2016-01-01) Zeybek, RAHMİ; Bacaksiz, AHMET; Sharifov, RASUL; SEVGILI, Emrah; Ay, YASİN; ZEYBEK, RAHMİ; BACAKSIZ, AHMET; SHARIFOV, RASUL; AY, YASİNWe report the case of a patient with situs inversus totalis, annuloaortic ectasia complicated by aortic insufficiency and mitral regurgitation which induced congestive heart failure. Both valvular lesions were repaired physiologically using aortic root sparing Yacoub 'remodeling' technique and mitral ring annuloplasty. Valve sparing techniques can be used effectively even in patients with complicated clinical scenarios (like dextrocardia and annuloaortic ectasia) to avoid the potential risks related to prosthetic valve implantation and lifelong anticoagulation therapy.