Publication: Decorin as a new treatment alternative in Peyronie-s disease: preliminary results in the rat model
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2013-04-01T00:00:00Z
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Akman, T.
Tefekli, A.
Armagan, A.
Kilicaslan, I.
Ozerman, B.
Tepeler, A.
Kadioglu, A.
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Abstract
The purpose of this study is to investigate the effect of decorin, a naturally occurring proteoglycan with anti-transforming growth factor beta (TGF-) activity, on the rat model of Peyronie-s disease (PD). Twenty-five adult male Sprague-Dawley rats were divided in three groups: I) TGF- (0.5g) injected (n: 8); II) TGF- injected and decorin treated (n: 8); and III) controls (n: 9). Decorin (0.5g per day) was given with intracavernous injection on the second, third, fourth and fifth day following TGF- injection. All rats underwent electrical stimulation of the cavernous nerve after 6weeks. Intracavernosal and arterial blood pressures were measured during this procedure. Cross-sections of the rat penises were examined using Mason trichrome and H&E stains. Statistical analyses were carried out using one-way anova. Histopathological examinations confirmed the Peyronie-s-like condition in TGF--injected rats, which exhibited a thickening of the tunica albuginea (TA), when compared to controls. Disorganisation of collagen on the TA was also prominent in TGF--injected rats, but not in decorin-treated and control rats. Decorin-treated rats showed significantly higher maximal intracavernosal pressure (MIP) responses to cavernous nerve stimulation, when compared to group 1 (P<0.05). Our results indicate that decorin antagonises the effects of TGF- in the rat model of PD and prevents diminished erectile response to cavernous nerve stimulation.
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Akman T., Tefekli A., Armagan A., Kilicaslan I., Ozerman B., Tepeler A., Kadioglu A., -Decorin as a new treatment alternative in Peyronie-s disease: preliminary results in the rat model-, ANDROLOGIA, cilt.45, ss.101-106, 2013