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Decorin as a new treatment alternative in Peyronie-s disease: preliminary results in the rat model

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dc.contributor.authorAkman, T.
dc.contributor.authorTefekli, A.
dc.contributor.authorArmagan, A.
dc.contributor.authorKilicaslan, I.
dc.contributor.authorOzerman, B.
dc.contributor.authorTepeler, A.
dc.contributor.authorKadioglu, A.
dc.date.accessioned2020-10-22T15:57:22Z
dc.date.available2020-10-22T15:57:22Z
dc.date.issued2013-04-01T00:00:00Z
dc.description.abstractThe purpose of this study is to investigate the effect of decorin, a naturally occurring proteoglycan with anti-transforming growth factor beta (TGF-) activity, on the rat model of Peyronie-s disease (PD). Twenty-five adult male Sprague-Dawley rats were divided in three groups: I) TGF- (0.5g) injected (n: 8); II) TGF- injected and decorin treated (n: 8); and III) controls (n: 9). Decorin (0.5g per day) was given with intracavernous injection on the second, third, fourth and fifth day following TGF- injection. All rats underwent electrical stimulation of the cavernous nerve after 6weeks. Intracavernosal and arterial blood pressures were measured during this procedure. Cross-sections of the rat penises were examined using Mason trichrome and H&E stains. Statistical analyses were carried out using one-way anova. Histopathological examinations confirmed the Peyronie-s-like condition in TGF--injected rats, which exhibited a thickening of the tunica albuginea (TA), when compared to controls. Disorganisation of collagen on the TA was also prominent in TGF--injected rats, but not in decorin-treated and control rats. Decorin-treated rats showed significantly higher maximal intracavernosal pressure (MIP) responses to cavernous nerve stimulation, when compared to group 1 (P<0.05). Our results indicate that decorin antagonises the effects of TGF- in the rat model of PD and prevents diminished erectile response to cavernous nerve stimulation.
dc.identifier.citationAkman T., Tefekli A., Armagan A., Kilicaslan I., Ozerman B., Tepeler A., Kadioglu A., -Decorin as a new treatment alternative in Peyronie-s disease: preliminary results in the rat model-, ANDROLOGIA, cilt.45, ss.101-106, 2013
dc.identifier.doi10.1111/j.1439-0272.2012.01318.x
dc.identifier.pubmed22670875
dc.identifier.scopus84874276028
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23726
dc.identifier.wosWOS:000315398900005
dc.titleDecorin as a new treatment alternative in Peyronie-s disease: preliminary results in the rat model
dc.typeArticle
dspace.entity.typePublication
local.avesis.id54fd40b7-471d-4d09-8208-21ceb523e479
local.publication.isinternational1
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