Publication: Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: experimental study
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Date
2019-12-01T00:00:00Z
Authors
Altintas, Ozge
Antar, Veysel
Baran, Oguz
Karatas, Ersin
Altintas, Mehmet Ozgen
Kesgin, Sidika
Buyukpinarbasili, Nur
KOÇYİĞİT, ABDÜRRAHİM
Asil, Talip
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Abstract
BACKGROUND: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malignant cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema.
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Altintas O., Antar V., Baran O., Karatas E., Altintas M. O. , Kesgin S., Buyukpinarbasili N., KOÇYİĞİT A., Asil T., -Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: experimental study-, JOURNAL OF NEUROSURGICAL SCIENCES, cilt.63, ss.714-722, 2019