Timokinon tedavisinin sporadik alzheimer modeli oluşturulmuş sıçan beyin dokusundaki mikroRNA ve mRNA ekspresyonu üzerindeki etkisinin araştırılması / Investigating the mechanism on expression of MRNA and microrna triggered by timoquinon treatment in brain of sporadic alzheimer's disease model rats

Abstract

Alzheimer's disease is one of the most common neurodegenerative diseases. Synaptic deficiency, neuronal damage and neuron loss in the hippocampal region in which memory and learning control are performed are among neuropathological findings of Alzheimer's Disease (AD). At the molecular level, in response to neuronal death and deficiencies in synaptic connections, regulations at the gene and protein levels occur in the apoptosis, neurogenesis, cell division and cycling, survival, etc. pathways. It has also been shown in both human and animal studies that microRNAs, known to be a major factor in controlling cell function at the epigenetic level, are also effective in Alzheimer's disease and rearranged during the disease progression. Thymoquinone (TQ) is the most important bioactive component found in Nigella sativa (Black cumin) in the ratio of 18.4-24%. In many previous studies, it has been shown that TQ has many beneficial effects such as anti-oxidative, anti-inflammatory, and anti-cancerogenic. Similarly, it has been reported that TQ is neuroprotective against to the pathologies of neurological disorders. However, there is no in vivo study on the mechanism of molecular action of TQ in the literature while there are in vitro studies related neuroprotective effect of TQ on AD. We therefore aimed to compare the effects of TQ in the amyloid beta (Aβ) and Streptozotocin (STZ) induced sporadic Alzheimer's models and to investigate the effect of TQ on the expression levels of AD-related genes and microRNAs in hippocampal tissues We believe that the data we obtain will shed light on the potency of TQ as a candidate molecule in Alzheimer's disease which has not yet had an effective therapy.

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