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Timokinon tedavisinin sporadik alzheimer modeli oluşturulmuş sıçan beyin dokusundaki mikroRNA ve mRNA ekspresyonu üzerindeki etkisinin araştırılması / Investigating the mechanism on expression of MRNA and microrna triggered by timoquinon treatment in brain of sporadic alzheimer's disease model rats

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dc.contributor.advisorAkbaş, Fahri
dc.contributor.advisorElibol, Birsen
dc.contributor.authorAydoğan, Tuğçe
dc.date.accessioned2020-07-15T16:28:12Z
dc.date.available2020-07-15T16:28:12Z
dc.date.issued2017en
dc.descriptionThesis (Master)--Bezmialem Vakıf University, Department of Biotechnology, Istanbul, 2017en
dc.description.abstractAlzheimer's disease is one of the most common neurodegenerative diseases. Synaptic deficiency, neuronal damage and neuron loss in the hippocampal region in which memory and learning control are performed are among neuropathological findings of Alzheimer's Disease (AD). At the molecular level, in response to neuronal death and deficiencies in synaptic connections, regulations at the gene and protein levels occur in the apoptosis, neurogenesis, cell division and cycling, survival, etc. pathways. It has also been shown in both human and animal studies that microRNAs, known to be a major factor in controlling cell function at the epigenetic level, are also effective in Alzheimer's disease and rearranged during the disease progression. Thymoquinone (TQ) is the most important bioactive component found in Nigella sativa (Black cumin) in the ratio of 18.4-24%. In many previous studies, it has been shown that TQ has many beneficial effects such as anti-oxidative, anti-inflammatory, and anti-cancerogenic. Similarly, it has been reported that TQ is neuroprotective against to the pathologies of neurological disorders. However, there is no in vivo study on the mechanism of molecular action of TQ in the literature while there are in vitro studies related neuroprotective effect of TQ on AD. We therefore aimed to compare the effects of TQ in the amyloid beta (Aβ) and Streptozotocin (STZ) induced sporadic Alzheimer's models and to investigate the effect of TQ on the expression levels of AD-related genes and microRNAs in hippocampal tissues We believe that the data we obtain will shed light on the potency of TQ as a candidate molecule in Alzheimer's disease which has not yet had an effective therapy.en
dc.description.abstract{{abstract}}
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18206
dc.language.isoentr_TR
dc.publisherBezmialem Vakıf Universityen
dc.subjectBiyoteknoloji = Biotechnologytr_TR
dc.subjectGenetik = Geneticstr_TR
dc.subjectNöroloji = Neurologytr_TR
dc.subjectAlzheimer hastalığı = Alzheimer diseasetr_TR
dc.subjectAlzheimer hastalığı = Alzheimer diseasetr_TR
dc.subjectAmiloid beta protein = Amyloid beta proteintr_TR
dc.subjectBeyin = Braintr_TR
dc.subjectMikro RNA = Micro RNAtr_TR
dc.subjectStreptozotosin = Streptozotocintr_TR
dc.subjectTimokinon = Thymoquinonetr_TR
dc.titleTimokinon tedavisinin sporadik alzheimer modeli oluşturulmuş sıçan beyin dokusundaki mikroRNA ve mRNA ekspresyonu üzerindeki etkisinin araştırılması / Investigating the mechanism on expression of MRNA and microrna triggered by timoquinon treatment in brain of sporadic alzheimer's disease model ratstr_TR
dc.typeThesis Masteren
dc.typeThesis Master
dspace.entity.typePublication
local.thesis.programnameBiotechnology Programen
local.thesis.termGüz Dönemitr_TR
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