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Parathyroid Allotransplant With a New Technique: A Prospective Clinical Trial.

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Aysan, E
ERCAN, C
IDIZ, UO
MUSLUMANOGLU, M

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2016-08-01

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Objectives: Parathyroid allotransplant is a valuable alternative in treating permanent hypoparathyroidism. However, it is a difficult process that requires several trained staff and advanced laboratory equipment, which makes the costs high. Here, we identify a new parathyroid allotransplant technique. Materials and Methods: After obtaining informed consent from patients, parathyroid cell suspensions obtained from 4 donors who had undergone a subtotal parathyroidectomy owing to chronic renal failure were transplanted in 10 patients with permanent hypoparathyroidism after short-term cell cultivation. Prednisolone were used as immunosuppressant for the first 10 days and discontinued thereafter. Results: Allograft function was observed in 7 patients (70%) at a mean follow-up of 12 months. Daily oral calcium and vitamin D supplementations discontinued totally in 7 patients. No major or minor complication was observed. Conclusions: Our technique is simple, fast, and has a low cost, with a 70% success rate at a mean follow-up of 12 months. It requires few staff, minimal equipment, and short-term immunosuppressant use for main tenance. The technical developments of parathyroid allotransplant, as mentioned in this study, may be important in treating permanent hypoparathyroidism

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Aysan E., ALTUG B., ERCAN C., Kesgin T., IDIZ U., MUSLUMANOGLU M., -Parathyroid Allotransplant With a New Technique: A Prospective Clinical Trial.-, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, cilt.14, ss.431-5, 2016

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