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Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin

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dc.contributor.authorVehapoglu, AYSEL
dc.contributor.authorGOKNAR, Nilufer
dc.contributor.authorTUNA, Rumeysa
dc.contributor.authorCakir, FATMA BETÜL
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.contributor.institutionauthorÇAKIR, FATMA BETÜL
dc.date.accessioned2019-10-05T14:30:08Z
dc.date.available2019-10-05T14:30:08Z
dc.date.issued2016-03-01
dc.description.abstractDrug-induced hemolytic anemia is an immune-mediated phenomenon that leads to the destruction of red blood cells. Here, we present a case of life-threatening ceftriaxone-induced hemolytic anemia (CIHA) in a previously healthy 3-year-old girl. We also reviewed the literature to summarize the clinical features and treatment of hemolytic anemia. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with high mortality. Our patient had a sudden loss of consciousness with macroscopic hematuria and her hemoglobin dropped from 10.2 to 2.2 g/dl over 4 hours, indicating that the patient had life-threatening hemolysis after an intravascular dose of ceftriaxone who had previously been treated with ceftriaxone in intramuscular form for six days. CIHA is associated with a positive direct antiglobulin test, revealing the presence of IgG in all cases and C3d in most cases. Our patient's direct antiglobulin test was positive for IgG (3+) and for C3d (4+). The case was managed successfully with supportive measures and intravenous immunoglobulin therapy. Ceftriaxone is used very frequently in children; an early diagnosis and proper treatment of hemolytic anemia are essential to improve the patient outcome. The pathophysiological mechanism is the same as for non-drug autoimmune hemolytic anemia. However, there is still no consensus treatment for CIHA. Intravenous immunoglobulin can be used in clinical emergencies, such as our case, or in refractory cases.en
dc.identifier10.1111/j.1365-4632.2004.02012.x
dc.identifier.citationVehapoglu A., GOKNAR N., TUNA R., Cakir F. B. , -Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin-, TURKISH JOURNAL OF PEDIATRICS, cilt.58, ss.216-219, 2016
dc.identifier.doi10.24953/turkjped.2016.02.016
dc.identifier.pubmed27976566
dc.identifier.scopus85003666471
dc.identifier.trdizinISSN: 0041-4301
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4061
dc.identifier.wosWOS:000389714300016
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleCeftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL JOURNAL OF DERMATOLOGY
local.avesis.id62c1f858-bdd5-4ec0-8a4c-b1c301721196
local.avesis.response3931
local.publication.isinternational1
relation.isAuthorOfPublicationb68333b8-8b35-4545-989f-bf6e27e7a81b
relation.isAuthorOfPublication4b01ee0e-c087-44d4-9581-4d73032d078e
relation.isAuthorOfPublication.latestForDiscovery4b01ee0e-c087-44d4-9581-4d73032d078e
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