Publication: Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin
dc.contributor.author | Vehapoglu, AYSEL | |
dc.contributor.author | GOKNAR, Nilufer | |
dc.contributor.author | TUNA, Rumeysa | |
dc.contributor.author | Cakir, FATMA BETÜL | |
dc.contributor.institutionauthor | VEHAPOĞLU TÜRKMEN, AYSEL | |
dc.contributor.institutionauthor | ÇAKIR, FATMA BETÜL | |
dc.date.accessioned | 2019-10-05T14:30:08Z | |
dc.date.available | 2019-10-05T14:30:08Z | |
dc.date.issued | 2016-03-01 | |
dc.description.abstract | Drug-induced hemolytic anemia is an immune-mediated phenomenon that leads to the destruction of red blood cells. Here, we present a case of life-threatening ceftriaxone-induced hemolytic anemia (CIHA) in a previously healthy 3-year-old girl. We also reviewed the literature to summarize the clinical features and treatment of hemolytic anemia. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with high mortality. Our patient had a sudden loss of consciousness with macroscopic hematuria and her hemoglobin dropped from 10.2 to 2.2 g/dl over 4 hours, indicating that the patient had life-threatening hemolysis after an intravascular dose of ceftriaxone who had previously been treated with ceftriaxone in intramuscular form for six days. CIHA is associated with a positive direct antiglobulin test, revealing the presence of IgG in all cases and C3d in most cases. Our patient's direct antiglobulin test was positive for IgG (3+) and for C3d (4+). The case was managed successfully with supportive measures and intravenous immunoglobulin therapy. Ceftriaxone is used very frequently in children; an early diagnosis and proper treatment of hemolytic anemia are essential to improve the patient outcome. The pathophysiological mechanism is the same as for non-drug autoimmune hemolytic anemia. However, there is still no consensus treatment for CIHA. Intravenous immunoglobulin can be used in clinical emergencies, such as our case, or in refractory cases. | en |
dc.identifier | 10.1111/j.1365-4632.2004.02012.x | |
dc.identifier.citation | Vehapoglu A., GOKNAR N., TUNA R., Cakir F. B. , -Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin-, TURKISH JOURNAL OF PEDIATRICS, cilt.58, ss.216-219, 2016 | |
dc.identifier.doi | 10.24953/turkjped.2016.02.016 | |
dc.identifier.pubmed | 27976566 | |
dc.identifier.scopus | 85003666471 | |
dc.identifier.trdizin | ISSN: 0041-4301 | |
dc.identifier.trdizin | trdizin | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/4061 | |
dc.identifier.wos | WOS:000389714300016 | |
dc.language.iso | en | |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.title | Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.article.journalname | INTERNATIONAL JOURNAL OF DERMATOLOGY | |
local.avesis.id | 62c1f858-bdd5-4ec0-8a4c-b1c301721196 | |
local.avesis.response | 3931 | |
local.indexed.at | PubMed | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.indexed.at | TrDizin | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | b68333b8-8b35-4545-989f-bf6e27e7a81b | |
relation.isAuthorOfPublication | 4b01ee0e-c087-44d4-9581-4d73032d078e | |
relation.isAuthorOfPublication.latestForDiscovery | 4b01ee0e-c087-44d4-9581-4d73032d078e |
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