Publication:
A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel

Simple item page
dc.contributor.authorGokkaya, Bengisu
dc.contributor.authorAtasoy, Sezen
dc.contributor.authorÇIRAKOĞLU, AYŞE
dc.contributor.authorARGÜDEN, YELDA
dc.contributor.authorKURU, RAHİYE DİLHAN
dc.contributor.authorYILMAZ, ŞÜKRİYE
dc.contributor.authorÖNGÖREN, ŞENİZ
dc.contributor.authorDEVİREN, AYHAN
dc.contributor.institutionauthorATASOY, SEZEN
dc.date.accessioned2022-08-20T17:09:27Z
dc.date.available2022-08-20T17:09:27Z
dc.date.issued2022-06-01T00:00:00Z
dc.description.abstractObjective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. Fin diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyorype or unsuccessful karyoryping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study. Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenctic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.
dc.identifier.citationGokkaya B., Atasoy S., ÇIRAKOĞLU A., ARGÜDEN Y., KURU R. D. , YILMAZ Ş., ÖNGÖREN Ş., DEVİREN A., -A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel-, BEZMIALEM SCIENCE, cilt.10, sa.3, ss.370-375, 2022
dc.identifier.doi10.14235/bas.galenos.2021.5638
dc.identifier.trdizin1171562
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30863
dc.identifier.wosWOS:000821859000016
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleA Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel
dc.typeArticle
dspace.entity.typePublication
local.avesis.id1de823b8-4e32-4224-bf09-3fd36dd3eaba
local.publication.isinternational1
relation.isAuthorOfPublication4cb2d797-b083-4232-9eda-1d1df30c18ae
relation.isAuthorOfPublication.latestForDiscovery4cb2d797-b083-4232-9eda-1d1df30c18ae
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel.pdf
Size:
367.36 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler
Bezmialem Science Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu