Publication:
Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension

Simple item page
dc.contributor.authorKumral, Zarife Nigar Ozdemir
dc.contributor.authorKolgazi, Meltem
dc.contributor.authorUstunova, SAVAŞ
dc.contributor.authorCakir, Ozguer Kasimay
dc.contributor.authorCevik, Ozge Dagdeviren
dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorYEGEN, BERRAK
dc.contributor.institutionauthorÜSTÜNOVA, SAVAŞ
dc.date.accessioned2019-10-05T13:49:42Z
dc.date.available2019-10-05T13:49:42Z
dc.date.issued2016-01-01
dc.description.abstractAlthough endogenous estrogen is known to offer cardiac and vascular protection, the involvement of estrogen receptors in mediating the protective effect of estrogen on hypertension-induced cardiovascular and renal injury is not fully explained. We aimed to investigate the effects of estrogen receptor (ER) agonists on oxidative injury, cardiovascular and renal functions of rats with renovascular hypertension (RVH). Female Sprague-Dawley rats were randomly divided as control and RVH groups, and RVH groups had either ovariectomy (OVX) or sham-OVX. Sham-OVX-RVH and OVX-RVH groups received either ER agonist diarylpropiolnitrile (1 mg/kg/day) or ER agonist propyl pyrazole triol (1 mg/kg/day) for 6 weeks starting at the third week following the surgery. At the end of the 9(th) week, systolic blood pressures were recorded, cardiac functions were determined, and the contraction/relaxation responses of aortic rings were obtained. Serum creatinine levels, tissue malondialdehyde, glutathione, superoxide dismutase, catalase levels, and myeloperoxidase activity in heart and kidney samples were analyzed, and Na+, K+-ATPase activity was measured in kidney samples. In both sham-OVX and OVX rats, both agonists reduced blood pressure and reversed the impaired contractile performance of the heart, while ER agonist improved renal functions in both the OVX and non-OVX rats. Both agonists reduced neutrophil infiltration, lipid peroxidation, and elevated antioxidant levels in the heart, but a more ER-mediated protective effect was observed in the kidney. Our data suggest that activation of ER might play a role in preserving the function of the stenotic kidney and delaying the progression of renal injury, while both receptors mediate similar cardioprotective effects.
dc.identifier
dc.identifier.citationKumral Z. N. O. , Kolgazi M., Ustunova S., Cakir O. K. , Cevik O. D. , ŞENER G., YEGEN B., -Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension-, CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.38, ss.500-509, 2016
dc.identifier.doi10.3109/10641963.2015.1116550
dc.identifier.pubmed27399230
dc.identifier.scopus84978161952
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3107
dc.identifier.wosWOS:000381406300002
dc.titleEstrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameNEURO-ONCOLOGY
local.avesis.id4b774d9c-f7b5-4e80-a7a4-bae26b6e06f5
local.avesis.response2977
local.publication.isinternational1
relation.isAuthorOfPublicationbebec550-3712-466a-8e2d-8f90006e62f6
relation.isAuthorOfPublication.latestForDiscoverybebec550-3712-466a-8e2d-8f90006e62f6
Files
Collections
Yayınlar - Eserler
Tıp Fakültesi
TR Dizin İndeksli Yayınlar Koleksiyonu