Publication: Experimental and clinical evidence of antioxidant therapy in acute pancreatitis
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Date
2012-10-21
Authors
Authors
Esrefoglu, MUKADDES
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Abstract
Oxidative stress has been shown to play an important
role in the pathogenesis of acute pancreatitis (AP). Antioxidants, alone or in combination with conventional
therapy, should improve oxidative-stress-induced organ
damage and therefore accelerate the rate of recovery.
In recent years, substantial amounts of data about the
efficiency of antioxidants against oxidative damage
have been obtained from experiments with rodents.
Some of these antioxidants have been found beneficial
in the treatment of AP in humans; however, at present
there is insufficient clinical data to support the benefits
of antioxidants, alone or in combination with conventional therapy, in the management of AP in humans.
Conflicting results obtained from experimental animals
and humans may represent distinct pathophysiological
mechanisms mediating tissue injury in different species. Further detailed studies should be done to clarify
the exact mechanisms of tissue injury in human AP.
Herein I tried to review the existing experimental and
clinical studies on AP in order to determine the efficiency of antioxidants. The use of antioxidant enriched
nutrition is a potential direction of clinical research
in AP given the lack of clues about the efficiency and
safety of antioxidant usage in patients with AP
Description
Keywords
acute pancreatitis
Citation
Esrefoglu M., -Experimental and clinical evidence of antioxidant therapy in acute pancreatitis.-, World journal of gastroenterology, cilt.18, ss.5533-41, 2012