Publication:
Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients

Simple item page
dc.contributor.authorKandaz, Cemre
dc.contributor.authorOnal, Burak
dc.contributor.authorOzen, Deniz
dc.contributor.authorDemir, Bulent
dc.contributor.authorAkkan, Ahmet Gökhan
dc.contributor.authorOzyazgan, Sibel
dc.contributor.institutionauthorAKKAN, AHMET GÖKHAN
dc.date.accessioned2021-01-21T20:59:28Z
dc.date.available2021-01-21T20:59:28Z
dc.date.issued2018-02-01T00:00:00Z
dc.description.abstractBackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis.
dc.identifier.citationKandaz C., Onal B., Ozen D., Demir B., Akkan A. G. , Ozyazgan S., -Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients-, JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.32, 2018
dc.identifier.doi10.1002/jcla.22247
dc.identifier.scopus85018407164
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28091
dc.identifier.wosWOS:000425109100023
dc.titleInvestigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7295d26b-e84e-4079-85c3-e2a226bc0d43
local.publication.isinternational1
relation.isAuthorOfPublication3d01b102-caf1-4fba-a467-f358f2f6d3c7
relation.isAuthorOfPublication.latestForDiscovery3d01b102-caf1-4fba-a467-f358f2f6d3c7
Files
Collections
Silinecekler