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Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients

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Date
2018-02-01T00:00:00Z
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Kandaz, Cemre
Onal, Burak
Ozen, Deniz
Demir, Bulent
Akkan, Ahmet Gökhan
Ozyazgan, Sibel
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Abstract
BackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis.
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Kandaz C., Onal B., Ozen D., Demir B., Akkan A. G. , Ozyazgan S., -Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients-, JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.32, 2018
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